Global Market Size, Forecast, and Trend Highlights Over 2025-2037
X-ray Photoelectron Spectroscopy Market size was over USD 762.2 million in 2024 and is estimated to reach USD 1.24 billion by the end of 2037, expanding at a CAGR of 4.2% during the forecast timeline, i.e., 2025-2037. In 2025, the industry size of x-ray photoelectron spectroscopy is evaluated at USD 794.2 million.
There is a growing demand for better delivery systems and therapeutic specificity in healthcare, which is fueling the market. These analyzers help to understand surface compositions and chemical characteristics of drugs, improving the efficacy of targeted therapies. Thus, electron spectroscopy is becoming an essential laboratory component in clinical trials and research-based developments. This is further testified by the rapid expansion in personalized therapy businesses. In this regard, a Research Nester report stated that the precision medicine industry is expected to reach USD 113.6 billion by 2025 and USD 757.4 billion by 2037, exhibiting a CAGR of 16.7%. Another NLM article registered a total of 1938 clinical trials in this category worldwide till December 2023.
Furthermore, spreading awareness about the importance of high-precision analytical tools across a wide spectrum of merchandise is heightening sales in the market. However, the payers’ pricing of instruments, associated with this field, is notably high and varies according to the type, specificity, and complexity. This also impacts the overall budget for service providers, making their offerings more expensive. Many research institutions and government facilities are now offering cost-effective services to mitigate this issue. For instance, a standardized payers’ pricing of performing X-ray photoelectron spectroscopy (XPS) analysis among academia in the U.S. is USD 100.0/hour: the Journal of Vacuum Science & Technology, May 2023.
X-Ray Photoelectron Spectroscopy Sector: Growth Drivers and Challenges
Growth Drivers
- Increasing investments in biopharmaceutical R&D: Equipment from the X-ray photoelectron spectroscopy market is widely used to evaluate biomaterials and formulations, making them a crucial part of biotechnology. In the context of surface interactions, various biopharma utilize this technology in developing new therapeutics, fueling demand in this sector. As a result, growth in this industry, along with rigorous R&D activities, is inflating the need for XPS. On this note, the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) reported that the global business of this category spent USD 198.0 billion on R&D in 2020. It further mentioned that over 9,000 compounds were under development during the same timeframe.
Number of Drugs Under Development in 2021
|
Type of Therapy |
Count of Drugs |
|
Oncology |
3,148 |
|
Immunology |
1,677 |
|
Neurology |
1,688 |
|
Infectious Disease |
1,488 |
Source: IFPMA Report
- Integration of high-tech features in operations: Technological advancements in spectrometry are revolutionizing the functionality and applicability of tools from the market. Companies from around the globe are putting efforts into introducing compact, user-friendly, and high-resolution systems, delivering better analytical overviews. The incorporation of automatic data processing features in these devices also brings convenience to operations, attracting customers from various industries to invest. For instance, in May 2021, Thermo Fisher Scientific introduced a fully automated XPS, Nexsa G2 Surface Analysis System, for multi-discipline material research and development.
Challenges
- Disparities in skill employment and affordability: Handling instruments from the market requires highly skilled operators. However, due to the complexity and required knowledge during these procedures, hiring the right professional becomes difficult, particularly in resource-constrained regions. Moreover, the additional expenses revolving around elongated sample preparation time and regular maintenance often discourage service providers from adopting these tools.
- Limitations in infrastructure and competency: Installing and operating XPS in laboratories comes with specific requirements, which may become challenging for organizations with limited budgets. The effectiveness of X-ray photoelectron spectroscopy market offerings depends on selective samples, making it non-useful for other materials. This may discourage organizations, seeking multi-modal functionality and affordability, from investing in this field, limiting wide adoption in this sector.
X-Ray Photoelectron Spectroscopy Market: Key Insights
|
Base Year |
2024 |
|
Forecast Year |
2025-2037 |
|
CAGR |
4.2% |
|
Base Year Market Size (2024) |
USD 762.2 million |
|
Forecast Year Market Size (2037) |
USD 1.24 billion |
|
Regional Scope |
|
X-Ray Photoelectron Spectroscopy Segmentation
Usage (Element Detection, Contamination Detection, Density Estimation, Empirical Formula Determination)
In x-ray photoelectron spectroscopy market, element detection segment is set to capture revenue share of over 37.1% by 2037. XPS has exceptional utility in precise surface analysis at an atomic level by identifying material characterization. Additionally, the high efficacy of these devices in acquiring detailed data on elemental composition, oxidation states, and chemical bonding makes this segment the major source of information for quality control in semiconductors and electronics production. Thus, the continuously escalating demand for these products is fueling escalation in this segment. In this regard, the Semiconductor Industry Association (SIA) revealed that worldwide semiconductor sales were valued at USD 56.5 billion in 2025, securing a 17.9% increment from 2024.
Application Area (Healthcare, Semiconductors, Electronics, Aerospace, Automotive, Others)
In terms of application area, the healthcare segment is poised to account for the largest revenue share in the X-ray photoelectron spectroscopy market throughout the forecasted timeframe. There is a wide range of utilities of XPS in clinical research and development, particularly in oncology. This is testified by an NLM study from April 2023, recognizing the efficacy of nanosized small extracellular vesicle composition in cancer screening and diagnosis with XPS. From targeted therapies to medical devices, there is a pivotal part of this analytical tool. This magnifies the contribution of healthcare to generating profitable revenue in this field. For instance, the business value of nanotechnology, associated heavy use of XPS, in medical devices was estimated at USD 3.0 billion in 2021 and is poised to attain USD 7.0 billion by 2030 (NLM report).
Our in-depth analysis of the global market includes the following segments:
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Usage |
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Application Area |
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Customize this ReportX-Ray Photoelectron Spectroscopy Industry - Regional Synopsis
North America Market Analysis
North America x-ray photoelectron spectroscopy market is estimated to hold revenue share of more than 43.2% by 2037. Considering the contribution of innovative laboratory equipment in the recent escalation of R&D in this region, both public and private authorities are heavily investing in strengthening infrastructure. In June 2021, as a part of the Defense University Research Instrumentation Program, the UMD Research Instrumentation Fund allocated USD 10.0 million for research equipment such as electron spectroscopy. Such initiatives are accelerating the pace of discovery in quantum technology, energy storage, and neuroscience. Further, ongoing biopharmaceutical findings and clinical trials are propelling XPS requirements forward.
The U.S. market is presenting an established landscape for securing great profit margins. The country has predominant captivity in drug development, particularly in the biopharma industry, making it a large consumer base for this field. Additionally, the U.S. witnessed 2,001,140 new and 611,720 death cases of cancer in 2024 (NLM). Another NLM article estimated the same to be 2,041,910 and 618,120 in 2025. This, pushes companies to invest more in oncology R&D and precision medicine, increasing the use of these surface analysis devices.
Canada is pledged to government support and funding, escalating clinical R&D and nationwide adoption in the market. The authorities in this country are now highly focused on bringing advancements in quantum materials, creating a surge in this sector. Their heavy investments are securing a continuous capital influx and acting as a financial cushion. For instance, in January 2025, the government of Canada allocated a total of USD 74.0 million grant to support 107 quantum science projects across the nation, aligning with the National Quantum Strategy.
APAC Market Statistics
Asia Pacific is projected to register the fastest growth in the X-ray photoelectron spectroscopy market during the forecast timeline. The region encompasses a wide spectrum of academic excellence in material science, which requires a large set of data about chemical composition, electronic structure, and bonding. This pushes the institutions to accommodate their research facility with specialty instruments such as XPS. For instance, in March 2025, Panjab University completed the installation of an X-ray photoelectron spectroscopy system at the department of SAIF/CIL, backed by funds from the Department of Science and Technology, New Delhi. In addition, APAC is expected to hold a significant revenue share of 30.5% in the precision medicine industry, which signifies a heightened demand for these tools in clinical trials.
Two growth factors are conjugately driving the India X-ray photoelectron spectroscopy market. One of them is the growing environmental concerns and the other is the enlarging semiconductor industry. The country is heavily equipping laboratories with advanced technologies, such as XPS, for harmful material detection to combat air pollution. On the other hand, the semiconductor industry of India is predicted to surpass USD 80.0 billion by 2026 and USD 110.0 billion by 2030, as per the International Trade Administration. In addition, the expanding national biotechnology business is also feeding progress in this sector.
China embarks on a higher need for surface analytical equipment due to progress in new drug development, technological innovations, and production capacity. The significant upliftment in manufacturing and developing new products in both the healthcare and electronics industries is fostering a large consumer base for XPS devices. This is further attracting global leaders to participate in this landscape. For instance, in November 2023, ULVAC-PHI founded a new subsidiary, ULVAC PHI Instruments Co., Ltd., in China to market its surface analysis tools efficiently.
Companies Dominating the X-Ray Photoelectron Spectroscopy Landscape
- Thermo Fisher Scientific Inc.
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
- Evan Analytical Group
- Intertek Group plc
- Yokogawa India Ltd.
- Nova Ltd.
- Kratos Analytical Ltd.
- FOCUS GmbH
The current dynamics of the X-ray photoelectron spectroscopy market are evolving with environmental concerns and higher efficacy. Key players are engaging their resources in rigorous R&D to mitigate the challenges associated with the existing modules. This is fostering a healthy competency among them and expanding their product portfolio in this sector. They are also focusing on expanding their territory by serving globally. For instance, in July 2022, Nova completed the delivery of its VeraFlex to a leading analog and mixed-signal device manufacturer in Israel. The XPS system was a continuation of the company’s strong business relationship with the customer overseas. Such key players are:
In the News
- In January 2025, Nova inaugurated a new manufacturing facility and operating office in Germany to leverage its global presence in delivering high-tech solutions related to XPS. The new unit is intended to double the chemical metrology production and R&D capacity, escalating automation, speed, and reliability in this sector.
- In October 2022, FOCUS launched a generation XPS analyzer, NanoESCA MARIS, at the LEEM PEEM 12 conference, held in Cordoba, Spain. The instrument is equipped with a 3-factor higher-resolution microscope lens, suitable for momentum and real space imaging spectroscopy.
Author Credits: Radhika Pawar
- Report ID: 7398
- Published Date: Mar 27, 2025
- Report Format: PDF, PPT
