 Treatment Market Overview.webp)
Necrotizing Ulcerative Gingivitis (NUG) Treatment Market size was over USD 1.13 billion in 2024 and is poised to exceed USD 4.99 billion by 2037, growing at over 12.1% CAGR during the forecast period i.e., between 2025-2037. In the year 2025, the industry size of necrotizing ulcerative gingivitis treatment is evaluated at USD 1.36 billion.
The growth of the market can be attributed to the rising number of people suffering from HIV or AIDs across the world. The presence of HIV or AIDs increases the risk of oral issues as HIV suppresses the immune system of the body making it weak to fight against any smaller disease or infection. HIV-associated gingivitis is called linear gingival erythema and is caused by herpes simplex virus type 1 (HSV-1). As per the statistical report of the World Health Organization, 38.4 million population around the globe was suffering from HIV by the end of 2021, and about 650,000 people died from HIV and other related illnesses in the same year.
Also, the poor oral habits of people across the world especially in rural areas owing to lack of knowledge is estimated to propel the market growth in the coming years. Oral hygiene is most important to avoid or prevent any kind of teeth, gum, and oral infections and diseases. The increasing number of people suffering from the formation of plaque around the teeth as well as swollen gums is estimated to drive the market growth during the forecast period. Regular brushing and flossing of teeth are very important for oral health and remove the presence of bacteria or fungi deposits. As per the reports of 2019, more than 30% of the American population failed to brush their teeth two times a day, and over 1.6 % of people admitted that they do not brush at least once a day.
Growth Drivers
Growing Prevalence of NUG and Other Oral Diseases with Lack of Awareness among People – Most people across the world do not consider dental problems as a major issue owing to a lack of knowledge. The presence of only fluoride water and the use of fluoride toothpaste for a longer time is also estimated to cause oral problems. Also, many low-income countries have less education regarding oral health and low or no spending capacity for healthcare. Additionally, the increasing age also causes many oral issues such as gum swelling, tooth decay, cavities, damaged teeth, and plaque formation which are left untreated.
As per the data from the Centers for Disease Control and Prevention in 2019, 1 in 5 people in the U.S. which is over 25% of the adult population are living with untreated dental cavities.
High Cases of Diabetes and Other Lifestyle Diseases with Poor Eating Habits – The incidence of diabetes increases the risk of worsening wounds and any other injuries as they are immune suppressed. The number of people diagnosed with diabetes in the U.S. was estimated to be over 28 million i.e., 11% population, and more than 37 million people which is 9% population had diabetes in 2019.
Growing Consumption of Tobacco and Other Related Products – More than 80% of people across the world who use tobacco are estimated to be present in low and middle-income countries as of 2022.
Increasing Population with Habits of Drinking Alcohol Across the World – Alcohol contains fermented bacteria that is used for the fermentation of alcohol which gets deposited on the teeth every time you drink. The percentage of people who binge drink alcohol as of 2020 was estimated to be over 20% in the U.S. and more than 6.5% of American people developed alcohol use disorder (AUD).
High Number of People Suffering from Nutritional Deficiencies – Lack of vitamin B12, iron, niacin, and vitamin B13 and low availability of essential nutrients is estimated to lead to gingivitis. The number of people suffering from undernourishment increased to more than 130 million people across the world during 2019-2022.
Challenges
Not everyone is worried about decayed teeth until it bothers with pain, swelling, and bleeding. People neglect oral hygiene as it does not affect them very much and poverty in many countries is also estimated to hinder the growth of the market in the coming years.
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Base Year |
2024 |
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Forecast Year |
2025-2037 |
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CAGR |
12.1% |
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Base Year Market Size (2024) |
USD 1.13 billion |
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Forecast Year Market Size (2037) |
USD 4.99 billion |
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Regional Scope |
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Treatment {Medication (Antiseptic Ointments, Antibiotics), Surgery (Gingival Grafting)}
The global necrotizing ulcerative gingivitis (NUG) treatment market is segmented and analyzed for demand and supply by treatment into medication which is further divided into antiseptic ointments, antibiotics, and others, and surgery which is divided into gingival grafting, and others. Out of these types, the medication segment is estimated to gain the largest market share of about 54% in the year 2037. The growth of the segment can be attributed to the increasing number of people using over-the-counter medications across the world. The rising popularity of topical applications such as antiseptic ointments and gel is estimated to hike the market growth during the forecast period. Topical applications help reduce pain, and swelling and promote a cooling effect on the apical surface which is estimated to rise the demand for medications in the coming years. Also, the rising prevalence of gingivitis elder population is estimated to fuel the market growth. More than 65% of the adult population is estimated to suffer from gingivitis across the world as of 2020. Medications such as metronidazole are the first line of drug therapy before going to any surgical procedure as it takes much time for recovery. Surgery is only preferred when the medications do not show any improvement. Antibiotics such as amoxicillin, tetracyclines, penicillin, clindamycin, and clavulanate, are used for the treatment of necrotizing ulcerative gingivitis.
Distribution Channel (Hospitals, Home Care, Pharmacies)
The global necrotizing ulcerative gingivitis (NUG) treatment market is also segmented and analyzed for demand and supply by distribution channel into hospitals, home care, pharmacies, and others. Amongst these four segments, the hospitals segment is expected to garner a significant share of around 29% in the year 2037. The treatment procedure for necrotizing ulcerative gingivitis involves regular cleaning and wiping of teeth. Also, the procedure involves hourly rinses with warm saline water or rinsing using 1.5% of hydrogen peroxide two times a day or 0.12% chlorhexidine which is usually seen in mouthwashes. This is predicted to help to remove any initial debridement present in the injury. The severe cases of necrotizing ulcerative gingivitis require all this care from the hospital to prevent further complications, hence hospital segment is estimated to drive the market growth in the coming years. The growing population with stress and sleep deprivation is also estimated to rise the prevalence of gingivitis disease which boosts the market growth in the coming years. More than 5% to 28% of adults struggle with chronic insomnia and over 29% to 50% of the elder population experience insomnia at least once as per the estimations in 2023 worldwide.
Our in-depth analysis of the global market includes the following segments:
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By Treatment |
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By Distribution Channel |
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North American Market Forecast
North America industry is estimated to hold largest revenue share of 32% by 2037. The growth of the market can be attributed majorly to the increasing prevalence of oral diseases in developed countries, including the US, backed by poor diet, and high cases of diabetes amongst the people. According to the data from the Centers for Disease Control and Prevention (CDC), more than 1 in every 4 adults, i.e., around 26% of the American population suffers from untreated tooth decay. Moreover, growing health awareness amongst the people and government initiatives to ensure efficient healthcare facilities, are estimated to boost the market growth. Besides this, the rising focus on the advancements in the diagnosis and treatment of different necrotizing gingivostomatitis diseases is also expected to drive market growth. The lack of pure drinking water which contains fluoride or other chemicals leads to teeth disorders and gum diseases thereby rises the chances of necrotizing ulcerative gingivitis and the growth of the market.
APAC Market Statistics
The Asia Pacific necrotizing ulcerative gingivitis (NUG) treatment market is estimated to be the second largest, registering a share of about 28% by the end of 2037. The growth of the market can be attributed to improving the public healthcare system, and growing awareness among people regarding oral hygiene. The increasing population across the region with stress, anxiety, and sleep disorders is estimated to drive market growth across the world. Education about healthy eating habits and mouth rising regularly twice a day or after each meal if required is estimated to reduce the occurrence of necrotizing ulcerative gingivitis disease. The increasing disposable income of people and living standards are changing the eating and drinking habits of people across the region which cause oral issues. Binge drinking of alcohol and regular consumption of tobacco is one of the major reasons for oral issues. The escalating use of antibiotics, ointments, topical pain relief, and solutions for oral health is estimated to drive market growth.
Europe Market Forecast
Further, the market in Europe, amongst the market in all the other regions, is projected to hold a share of 22% by the end of 2037. The growth of the market can be attributed majorly to the increasing preference for oral health across the region. The growing number of hospitals and rising education programs to prevent the drinking of fluoride water are estimated to boost market growth. The increasing number of people suffering from insomnia owing to work and family stress is rising the risk of gingivitis disease. The poor availability of nutritional diets and lack of proper food supply in underdeveloped countries of the region are also anticipated to drive market growth in the coming years. The negligence among people regarding oral health and ignoring issues such as tooth damage, loose teeth, tooth decay, and formation of plaque is expected to propel the growth of the market in this region.
 Treatment Market Share.webp)
Sanofi S.A. declared an agreement with Septodont to divest a portfolio of the four dental care brands which include Ultracain, Rodogyl, Birodogyl, and Dontisolon, and medical devices. The portfolio contains medicines that are useful for both during and after dental operations.
U.S. Food and Drug Administration recalled a GUM PerioSheild, an oral health rinse of SUNSTAR as it was found contaminated with Burkholderia cepacian microorganisms.
Author Credits: Radhika Pawar
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