Global Market Size, Forecast, and Trend Highlights Over 2025-2037
Cryo-electron Microscopy Market size was valued at USD 1.7 billion in 2024 and is anticipated to surpass USD 6.4 billion by 2037, registering a CAGR of 11.7% during the forecast timeline i.e 2025-2037. In 2025, the industry size of cryo-electron microscopy is assessed at USD 1.9 billion.
The cryo-electron microscopy market is witnessing upward growth trajectory with increasing need for high-resolution structure determination of complex biomolecular species. Moreover, the acknowledgment of the power of cryo-EM for structural determination of macromolecules at near atomic resolution without forgoing the advantage of conventional methods such as X-ray crystallography, particularly for examining membrane proteins and large macromolecular complexes. For instance, in August 2024, IIT Kanpur inaugurates National Cryo-EM facility to advance structural biology research and aid in visualizing in-depth understanding of molecules.
Moreover, machine learning and artificial intelligence algorithms integration into particle picking and structure refinement is reducing experimentation and research speed protocols. For instance, in July 2023, in Andover, Massachusetts, Generate Biomedicines opened a cryo-electron microscopy (cryo-EM) lab comprising of latest AI driven technologies that claims to speed up its search for novel protein-based treatments for infectious, immunological, and oncological conditions. This convergence of technological advancement, and rising use in life sciences justify the consistent rise of the cryo-electron microscopy market.
Cryo-electron Microscopy Sector: Growth Drivers and Challenges
Growth Drivers
- Rising need for high resolution structural elucidation: The cryo-electron microscopy market is going through the rapid development growth that is driven primarily by rising need for high-resolution structural elucidation of complex biomolecules. For instance, in January 2023, INL inaugurated the state-of-the-art Cryo-Electron Microscope that helps to study new diseases that is essential to structural biology and medical research, enabling precision in the observation of cells and their constituent parts. It allows researchers to see molecular details of interaction and mechanism, providing insights into drug research and general biology studies, driving the market growth rate.
- Expanding applications of life sciences: The cryo-electron microscopy market is expanding exponentially due to its rising use in all areas of bio life science. It is coping up the pace with the growing recognition of the power of cryo-EM to define intricate biological structure beyond its routine protein study to virology, cell biology, and structural genomics. For instance, in September 2023, the Structural Genomics Consortium (SGC) and X-Chem have joined forces to develop new chemical tools for studying human proteins. These expanding applications provide a platform to examine complex cell processes, viral processes, and macromolecular interactions.
Challenges
- Complexity in sample preparation: A major challenge to the cryo-electron microscopy market is the inherent sample preparation issue. The technical hurdle, native macromolecular structure preservation by high-fidelity and precise vitrification method used in cryo electron microscope is highly specialized and demands strict environmental control. Biological samples' susceptibility to artifacts during preparation and reproducibility issues in the attainment of ice embedding and best particle distribution always leads to second-best data quality and low throughput. Technical complexity with the requirement for considerable training and substantial resource intensity prevents universal access and undervalues cryo-EM techniques.
- Data processing and analysis: The prominent challenge in the cryo-electron microscopy market is processing raw electron micrographs to high-resolution three-dimensional reconstructions. This scenario relies on computationally advanced algorithms as well as massive processing power. Such indigenous particle selection, image registration, and structure optimization problems, combined with application-specific software and know-how demands, put a throughput limit on the procedure. Hence, it needs for large computer hardware and application-specific analysis methods reduces effective interpretation of the information and is able to make the time for qualitative structural data greater, and thus limiting the throughput and accessibility of cryo-EM.
Cryo-electron Microscopy Market: Key Insights
|
Base Year |
2024 |
|
Forecast Year |
2025-2037 |
|
CAGR |
11.7% |
|
Base Year Market Size (2024) |
USD 1.7 billion |
|
Forecast Year Market Size (2037) |
USD 6.4 billion |
|
Regional Scope |
|
Cryo-electron Microscopy Segmentation
Product Type (Scanning Electron Microscopes, Transmission Electron Microscopes, Accessories & Software)
Transmission segment is set to dominate cryo-electron microscopy market share of around 50.3% by the end of 2037, attributed to its capability for greater resolution. For instance, in June 2023, a next generation scanning transmission electron microscope was unveiled by Thermo Fisher Scientific for use in high-volume semiconductor production. The new Metrios 6 (S)TEM is designed to speed up transmission electron microscopy (TEM) data collecting and boost productivity. This technology base, being adaptable to next-generation computation algorithms in image re-construction and processing, guarantees TEM's core position in leading the expansion of the cryo-EM market and in making front-line science in structural biology possible.
End user (Academic & Research Institutions, Pharmaceutical & Biotechnology Companies)
The pharmaceutical & biotechnology companies segment is emerging as one of the most prominent segments in the cryo-electron microscopy market being imperative to accelerate drug discovery and development by embracing high-resolution structural information. For instance, in March 2021, a licensing agreement for the manufacturing and sale of Cryo Workflow Tools, was signed by Delmic Cryo B.V. and Max-Planck-Innovation GmbH. The goal of commercializing the tool is to reduce the ice contamination and overcoming a significant challenge in the cryo electron tomography (cryo-ET) workflow. Moreover, the very requirement of connecting intricate architectures of drug targets such as membrane proteins and macromolecular assemblies to render drug design a rational endeavour and maximize therapeutic performance.
Our in-depth analysis of the global market includes the following segments:
|
Product Type |
|
|
Application |
|
|
End user |
|
Want to customize this research report as per your requirements? Our research team will cover the information you require to help you take effective business decisions.
Customize this ReportCryo-electron Microscopy Industry - Regional Synopsis
North America Market Statistics
North America in cryo-electron microscopy market is estimated to capture over 42.1% revenue share by 2037, characterized by businesses and research institutes incorporating cryo-electron microscopy into their processes, and enhancing its adaptability and commercialization. Furthermore, the expansion of cryo-electron microscopy has also been driven by partnerships and collaborations, which have resulted in the sharing of resources and the exchange of information within the region.
The most significant growth driver in the U.S. cryo-electron microscopy market is the development of cutting-edge techniques to render efficiency in biological studies for breakthrough of molecules. For instance, in January 2025, UCLA's next-generation electron microscope gave a new way to perceive dynamic structures of viral proteins in motion with its Krios G4 cryo-electron microscopes. It is done by revealing atomic features smaller than the visible light wavelength and rendering them in three dimensions. It is anticipated to aid in new discoveries and advancements in treating Alzheimer's and cancer research owing to its doubled resolution and nine times speed of image data acquisition.
In Canada the growth in the cryo-electron microscopy market is growing rapidly due to the government’s initiatives and support through funding in R&D activities for enhancing medical science approaches. For instance, in March 2025, to create long-term domestic biomanufacturing capacity and creative solutions, using the strategic innovation fund, the government of Canada announced a USD 62 million investment to support Entos Pharmaceuticals' (Entos) USD 198.5 million initiative. With this donation, a 103,000-square-foot building that includes a biomanufacturing facility and an R&D center will be constructed.
Asia Pacific Market Analysis
The Asia Pacific cryo-electron microscopy market is expanding at a rapid pace owing to the popularity gained by the structural characterization of therapeutic targets using cryo-EM in the quickening of drug development and discovery. In addition, the government and private organizations are investing more in research and development, which is propelling technological breakthroughs in microscopy and resulting in the introduction of new products with improved features.
In India, the cryo-electron microscopy market is spurred by the high levels of collaborations and acquisitions between private businesses, research groups, and academic institutions that has hasten the creation and use of this cutting-edge technology. For instance, in January 2025, NanoImaging Services acquired Proteos, Inc. Through this strategic purchase, Proteos' protein production expertise and NIS's industry-leading cryo-EM technologies are combined to provide clients looking for structure-based drug discovery and protein production services with an integrated offering. These moves make it possible to pool resources, funds, and knowledge, which spurs innovation and broadens the application of cryo-electron microscopy across a range of scientific domains.
In China, the market is witnessing substantial growth owing to the government’s strong emphasis on making the country self-reliant through leveraging suffice technological and financial aid in discovering new and effective equipment in medical field. For instance, in January 2024, the TH-F120 is China's first domestically manufactured commercial transmission electron microscope created in Guangzhou's Huangpu area. This has eliminated the nation's total dependency on imported transmission electron microscopes and represents a major advancement in the production of electron guns, the fundamental technology of transmission electron microscopes.
Companies Dominating the Cryo-electron Microscopy Landscape
- ZEISS International
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
- Thermo Fisher Scientific Inc
- OPTIKA
- Olympus Corporation
- Leica Microsystems
- Gatan
- Generate Biomedicines
- Helmut Hund Gmbh
There are major competitors in the highly fragmented global cryo-electron microscopy market that are making significant investments in R&D to improve the capabilities, resolution, and workflows of cryo-electron microscopy devices. The enhanced capabilities help the companies in making cryo electron microscopes more approachable and user-friendly. For instance, in May 2024, the new electron microscope JEM-120i, created with the ideas of compact, easy to use, and expandable was released by JEOL. In order to meet these demands, the JEM-120i has developed into a next-generation microscope that is simple for both novice and expert users to operate, from operation to maintenance.
Here's the list of some key players:
In the News
- In September 2024, MSK's new fourth-generation Krios microscope targets samples that have been flash frozen at -180 C (-292 F), using electrons traveling at two-thirds the speed of light. The resulting data is processed, creating frame-by-frame stills and 3D videos that show basic biological machinery in action.
- In May 2023, Revvity, Inc. introduced three new imaging systems, which is intended to spur innovation in a variety of preclinical research applications. These new developments comprise the next-generation IVIS Spectrum 2 and the IVIS SpectrumCT imaging systems and the QuantumTM GX3 microCT structural imaging system.
Author Credits: Radhika Pawar
- Report ID: 7430
- Published Date: Apr 01, 2025
- Report Format: PDF, PPT
