Single Cell Genome Sequencing Market Trends

Growth Drivers

• Rising demand for precision medicine: The proven efficiency of products from the market, such as detailed analysis of genetic heterogeneity, assisting in early disease detection, remarkably drives the market growth. In this context, NIH January 2022 revealed that recent advances in single-cell sequencing technologies, such as single-cell epigenome sequencing, lineage tracing, and spatial transcriptomics, have productively enhanced resolution and accuracy in understanding cellular heterogeneity.
• Advancements in sequencing platforms: Preceding innovations in NGS technologies, automation, and bioinformatics are readily driving business in the single cell genome sequencing market. In February 2025, Roche announced the introduction of sequencing by expansion (SBX) technology, which is combined with an innovative sensor module, offers ultra-rapid, high-throughput sequencing that is both flexible and scalable for a wide range of applications, hence suitable for standard market growth.
• Funding grants from governing bodies: The aspect of continued funding from major research bodies is driving academic and clinical adoption in the market. For instance, in July 2025, Bigelow Laboratory for Ocean Sciences reported that it received nearly USD 3.5 million from the National Science Foundation to advance environmental single-cell genomics research to expand potential applications in biotechnology and marine ecosystem science, thus denoting a positive market outlook.

Historic Global Cancer Burden: Incidence and Mortality Statistics (2020)

Source: WHO 2025

Revenue Opportunities in Single Cell Genome Sequencing (2024-2025)

Source: Company Official Press Releases

Challenges

• Extensive technical complexity: This aspect poses a major challenge to the single cell genome sequencing market since it involves isolating and analyzing genetic material from individual cells, which causes considerable complexities. Besides, this data is quite often sparse, noisy, and high-dimensional, making it challenging to process with standard genomic tools. Therefore, this results in overtime consumption, thereby increasing the risk of inconsistent or inaccurate results.
• Increased equipment and consumable costs: The increasing costs of single-cell genome sequencing make it challenging for small-scale manufacturers to leverage them. Besides these advanced instruments, specialized reagents and high-throughput consumables are necessary for single-cell workflows, which are expensive and often require continued investment. Also, the necessity of a skilled workforce is highly essential for operation and maintenance, adding to the operational costs, thereby hindering widespread adoption.