Single Cell Genome Sequencing Market Size & Share, by Type (Reagents, Instruments); Technology; Disease Area; Application; Workflow; End use - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2026-2035

  • Report ID: 2666
  • Published Date: Sep 05, 2025
  • Report Format: PDF, PPT

Single Cell Genome Sequencing Market Outlook:

Single Cell Genome Sequencing Market size was valued at USD 3.6 billion in 2025 and is projected to reach approximately USD 21.2 billion by the end of 2035, rising at a CAGR of about 16.5% during the forecast period, i.e., 2026 to 2035. In 2026, the industry size of single cell genome sequencing is anticipated at USD 4.2 billion.

The heightened demand for genomic analysis in precision medicine, oncology, immunology, and developmental biology is the key factor behind the robust growth of the single cell genome sequencing market. As evidence WHO in February 2025 stated that cancer accounted for approximately 10 million deaths in a year, representing 1 in 6 of all global deaths. The report further stated that the most prevalent cancers were breast with 2.3 million cases and lung with 2.2 million. Hence, this highlights the urgent need for technologies such as single-cell genome sequencing, which are proven to provide high-resolution insights into tumor heterogeneity.

Furthermore, preceding innovations in terms of sequencing platforms, sample preparation, and data analytics are enhancing scalability and accuracy, thereby fostering a profitable business environment. As per the May 2023 NHGRI data cost of producing a sequenced human genome, including reagents, labor, instruments, and data processing, is reported to be below USD 1,000. Therefore, this significant cost reduction is readily accelerating the adoption of genome sequencing in clinical and research settings across different nations.

Single Cell Genome Sequencing Market Size
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Growth Drivers

  • Rising demand for precision medicine: The proven efficiency of products from the market, such as detailed analysis of genetic heterogeneity, assisting in early disease detection, remarkably drives the market growth. In this context, NIH January 2022 revealed that recent advances in single-cell sequencing technologies, such as single-cell epigenome sequencing, lineage tracing, and spatial transcriptomics, have productively enhanced resolution and accuracy in understanding cellular heterogeneity.
  • Advancements in sequencing platforms: Preceding innovations in NGS technologies, automation, and bioinformatics are readily driving business in the single cell genome sequencing market. In February 2025, Roche announced the introduction of sequencing by expansion (SBX) technology, which is combined with an innovative sensor module, offers ultra-rapid, high-throughput sequencing that is both flexible and scalable for a wide range of applications, hence suitable for standard market growth.
  • Funding grants from governing bodies: The aspect of continued funding from major research bodies is driving academic and clinical adoption in the market. For instance, in July 2025, Bigelow Laboratory for Ocean Sciences reported that it received nearly USD 3.5 million from the National Science Foundation to advance environmental single-cell genomics research to expand potential applications in biotechnology and marine ecosystem science, thus denoting a positive market outlook.

Historic Global Cancer Burden: Incidence and Mortality Statistics (2020)

Cancer Type

New Cases (2020)

Deaths (2020)

Breast

2.26 million

685,000

Lung

2.21 million

1.80 million

Colon & Rectum

1.93 million

916,000

Source: WHO 2025

Revenue Opportunities in Single Cell Genome Sequencing (2024-2025)

Company Name

Initiative

Year

Revenue Opportunity

Almac Diagnostic Services

Launched single-cell RNA-Seq services with the 10x Genomics platform

2025

Attracted biopharma clients for biomarker discovery and precision medicine

Bio-Rad Laboratories

Released ddSEQ 3' RNA-Seq Kit with integrated analysis software

2024

Tapped cost-sensitive researchers with a complete, affordable workflow

MDC-BIMSB (Ashley Sanders)

Developed a DNA-focused single-cell sequencing technique

2024

Opened new research markets in autoimmune and inflammatory diseases

Source: Company Official Press Releases

Challenges

  • Extensive technical complexity: This aspect poses a major challenge to the single cell genome sequencing market since it involves isolating and analyzing genetic material from individual cells, which causes considerable complexities. Besides, this data is quite often sparse, noisy, and high-dimensional, making it challenging to process with standard genomic tools. Therefore, this results in overtime consumption, thereby increasing the risk of inconsistent or inaccurate results.
  • Increased equipment and consumable costs: The increasing costs of single-cell genome sequencing make it challenging for small-scale manufacturers to leverage them. Besides these advanced instruments, specialized reagents and high-throughput consumables are necessary for single-cell workflows, which are expensive and often require continued investment. Also, the necessity of a skilled workforce is highly essential for operation and maintenance, adding to the operational costs, thereby hindering widespread adoption.

Single Cell Genome Sequencing Market Size and Forecast:

Report Attribute Details

Base Year

2025

Forecast Year

2026-2035

CAGR

16.5%

Base Year Market Size (2025)

USD 3.6 billion

Forecast Year Market Size (2035)

USD 21.2 billion

Regional Scope

  • North America (U.S., and Canada)
  • Asia Pacific (Japan, China, India, Indonesia, Malaysia, Australia, South Korea, Rest of Asia Pacific)
  • Europe (UK, Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Latin America (Mexico, Argentina, Brazil, Rest of Latin America)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)

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Single Cell Genome Sequencing Market Segmentation:

Type Segment Analysis

The instruments segment is projected to garner the largest revenue share of 59.5% in the market during the forecast timeline. The dominance of this subtype is effectively attributed to the continued innovations in high-throughput sequencing platforms for clinical and research environments. NIH in August 2022 revealed that FACS is widely used for marker-based sorting but requires high cell numbers and may cause cellular damage. Besides, microfluidic platforms, such as droplet-based systems, offer high-throughput, precise separation with integrated amplification, reducing pipetting errors and improving efficiency, hence a wider segment scope.

Technology Segment Analysis

Next-generation sequencing segment is expected to gain a share of 45.3% in the single cell genome sequencing market by the end of 2035. Cost efficiency, scalability, and capacity for deep genomic and transcriptomic profiling at the single-cell level are key factors behind this leadership.  In July 2024, Thermo Fisher Scientific declared a partnership with the National Cancer Institute for the myeloMATCH precision medicine trial targeting AML and MDS. The initiative uses Thermo Fisher’s NGS technology for rapid genomic profiling of patient samples. Hence, this is the evidence for a wider market scope.

Disease Area Segment Analysis

Cancer segment is predicted to grow at a considerable rate with a share of 40.9% in the market during the discussed timeframe. This is an area of growth since single-cell sequencing unlocks tumor heterogeneity, driver mutations, and clonal evolution, which are highly essential for precision oncology. In February 2025, Takara Bio USA, Inc., a subsidiary of Takara Bio Inc., introduced two new single-cell NGS profiling technologies designed to advance oncology research. The newly launched Shasta Total RNA-Seq and Shasta Whole-Genome Amplification Kits offer high-throughput, automated solutions for single-cell transcriptome and genomic analysis.

Our in-depth analysis of the global market includes the following segments:

Segment

Subsegments

Type

  • Reagents
  • Instruments

Technology

  • Next Generation Sequencing (NGS)
  • Circulating Cells
  • Genomic Variation
  • Cell Differentiation
  • PCR / qPCR
  • Microarray
  • MDA (Multiple Displacement Amplification)

Disease Area

  • Cancer
  • NGS
  • PCR / qPCR
  • Microarray
  • Immunology
  • Prenatal Diagnosis
  • Neurobiology
  • Microbiology
  • Others

Application

  • Circulating Cells
  • Genomic Variation
  • Cell Differentiation / Reprogramming
  • Subpopulation Characterization
  • Others

Work Flow

  • Single Cell Isolation
  • Sample Preparation
  • Genomic Analysis

End use

  • Academic & Research Laboratories
  • Biotechnology & Biopharmaceutical Companies
  • Clinics
  • Others
Vishnu Nair
Vishnu Nair
Head - Global Business Development

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Single Cell Genome Sequencing Market - Regional Analysis

North America Market Insights

North America is poised to dominate with the largest revenue share of 35.6% in the single cell genome sequencing market by the end of 2035. The region benefits from the advancements in genomics and continued investments in precision medicine. In May 2023, Pfizer and Thermo Fisher Scientific together announced that they are expanding access to next-generation sequencing based cancer testing in over 30 countries, thereby aiming to improve localized testing capabilities for breast and lung cancer, enabling quicker diagnosis and more targeted treatment decisions.

U.S. market of single cell genome sequencing is at the forefront globally, which is growing owing to the presence of leading biotechnology firms, advanced research institutions, and major healthcare providers. In March 2025, researchers at the Herbert Irving Comprehensive Cancer Center unveiled DEFND-seq, which is a new single-cell sequencing method that enables simultaneous RNA and DNA analysis from thousands of cells more cost-effectively and at a greater scale, hence benefiting overall market growth.

Canada is also a key contributor to the regional market, effectively fueled by the government-funded genomics programs and collaborative public-private research initiatives. In March 2025, Genome Canada announced the Canadian Precision Health Initiative (CPHI), with a total USD 81 million federal investment and projected total funding of USD 200 million. Besides, this national effort is predicted to create the country’s largest-ever human genomic database, sequencing over 100,000 genomes to reflect Canada’s diverse population.

Cost of Genome Sequencing Over Time

Year

Cost per Human Genome

Notes

2021

USD 600

Enables cost-effective single-cell sequencing

2022

USD 500

Further boosts accessibility and throughput

Source: NHGRI

APAC Market Insights

Asia Pacific is considered to be the fastest-growing region in the regional single cell genome sequencing market from 2026 to 2035. The region’s progression in this field is facilitated by the ever-increasing investment in biotechnology and expanding healthcare infrastructure. Meanwhile, the major countries such as China, India, Japan, South Korea, and Australia are continuously making investments in genomic research, with strong government support.  Besides, the region hosts a large population base and an increasing burden of chronic as well as genetic diseases, which provide an encouraging opportunity for firms to capitalize on this sector.

China is readily blistering growth in the regional market, facilitated by massive government funding under initiatives such as the China Precision Medicine Initiative and heightened demand for personalized therapies. In November 2024, Novogene participated in the TusPark UK China Series event, which is called Entering the Genomics Industry in China. It was also stated that 10% of its yearly revenue came from China and emphasized the importance of international collaboration to drive innovation in genomics, thereby positively impacting market growth.

India is also continuously growing in the Asia Pacific’s single cell genome sequencing market, owing to the rising awareness of genomics and increasing healthcare R&D. In this regard, at the Illumina India Genomics Summit, held in August 2024, the company announced the launch of a Global Capability Center in Bengaluru to grow its technology workforce and support global customers.  The company also stated that conditions such as tuberculosis, HIV/AIDS, malaria, rare diseases, and cancer, expanding genomics access is seen as key to advancing healthcare.

Asia-Pacific Healthcare and Cancer Care Indicators (2022-2023)

Category

Range / Value

Notes

Healthcare Spending Per Capita

USD 2,189 to USD 4,880

Except Brunei (USD 633)

Cancer Drug Expenditure Per Capita

USD 30 to USD 138

Comprehensive health coverage

Healthcare Financing Model

50% to 84%

Co-payments >30% in some countries

Out-of-Pocket Spending

44% to 76%

Higher OOP due to less universal coverage

Source: NIH

Europe Market Insights

Europe market is receiving support from robust research infrastructure and a collaborative scientific community. The region also benefits from heavy investments in personalized medicine and favourable regulatory frameworks. In March 2022, Macrogen Europe announced that it is expanding its single cell sequencing services, offering a wider range of options for input material, DNA library preparation, and data analysis. It also stated that the enhancement enables researchers with extremely detailed transcriptomic data, which is crucial for fields such as immunology and oncology.

U.K. holds a strong position in the regional single cell genome sequencing market, which is effectively propelled by research institutions such as the Wellcome Sanger Institute and substantial government initiatives. In August 2023, Almac Diagnostic Services announced a major expansion of its Next Generation Sequencing capabilities with the installation of the first Illumina NovaSeq X Plus instrument in Northern Ireland and the entire island of Ireland. Besides, this investment enhances Almac’s DNA and RNA sequencing services, boosting capacity, speed, accuracy, and cost-efficiency for biomarker discovery in terms of precision medicine.

France is gaining enhanced traction in the market, facilitated by a huge focus on biomedical research and a strong healthcare system that provides ground for the integration of single cell technologies into clinical and pharmaceutical research. For instance, in November 2022, Macrogen Europe announced the inauguration of a Sanger sequencing laboratory in Paris to better serve researchers in France. This new facility offers faster sample shipment and delivers results within 24 hours, maintaining their range of services, including Sanger sequencing, identification, and fragment analysis, hence suitable for standard market growth.

Single Cell Genome Sequencing Market Share
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Key Single Cell Genome Sequencing Market Players:

    The organizations involved in the single-cell genome sequencing market are implementing numerous strategies to secure their global positions. Intensive R&D to improve scalability and collaborations with pharmaceutical and academic institutions are a few innovative steps taken by these pioneers. On the other hand, the specialized firms are competing in terms of niche and cost-effective platforms. The landscape is further evolving with strong participation from Asia-based players who are focusing on clinical translation.

    Here is a list of key players operating in the global market:

    Company Name

    Country

    Market Share (2024)

    Industry Focus

    10x Genomics, Inc.

    U.S.

    25.7%

    The dominant leader providing integrated solutions (Chromium systems) for single-cell gene expression, epigenetics, and immune profiling

    Becton, Dickinson and Company (BD)

    U.S.

    12.8%

    Offers the BD Rhapsody platform for high-throughput single-cell multi-omics analysis, focused on immunology and oncology

    Illumina, Inc.

    U.S.

    10.4%

    The leading NGS platform provider; its sequencers (NovaSeq, NextSeq) are the primary engines for generating single-cell sequencing data

    Thermo Fisher Scientific Inc.

    U.S.

    9.8%

    Provides a vast portfolio of sequencers (Ion GeneStudio), library prep kits (AmpliSeq), and reagents for the entire single-cell workflow

    QIAGEN N.V.

    Netherlands

    7.2%

    Offers sample preparation technologies (QIAseq FX kits) and bioinformatics solutions for single-cell analysis

    Bio-Rad Laboratories, Inc.

    U.S.

    xx%

    Known for its Droplet Digital PCR technology and the ddSEQ Single-Cell Isolator for scRNA-seq library prep

    Pacific Biosciences (PacBio)

    U.S.

    xx%

    Specializes in long-read HiFi sequencing applied to single-cell genomics to resolve complex isoforms and variations

    Oxford Nanopore Tech plc

    UK

    xx%

    Provides real-time long-read sequencing (MinION), enabling direct RNA and full-length transcript analysis from single cells

    BGI Genomics

    China

    xx%

    A major genomics service provider offering DNBSEQ platforms and extensive single-cell omics services.

    NanoString Technologies, Inc.

    U.S.

    xx%

    A leader in spatial genomics with its GeoMx and CosMx platforms for highly multiplexed single-cell in situ analysis

    Parse Biosciences

    U.S.

    xx%

    Offers a scalable, instrument-free single-cell RNA sequencing platform (Evercode) for very large studies

    Fluidigm Corporation

    U.S.

    xx%

    Provides microfluidics-based systems (Polaris, Juno) for automated single-cell preparation and targeted analysis

    Singleron Biotechnologies

    Germany

    xx%

    Develops innovative single-cell sequencing solutions and automated instruments (Singleron Matrix) for high-throughput analysis

    Dolomite Bio

    UK

    xx%

    Specializes in microfluidic-based solutions (Nadia instrument) for single-cell isolation and encapsulation

    RareCyte, Inc.

    U.S.

    xx%

    Develops platforms for rare cell isolation from liquid biopsies, integrating single-cell retrieval and NGS prep

    MedGenome Labs Pvt. Ltd.

    India

    xx%

    A leading genomic service provider in South Asia offering NGS-based services, including single-cell sequencing

    Proteona Pte. Ltd.

    Singapore

    xx%

    An integrated biotech company that combines single-cell sequencing with proprietary bioinformatics for oncology

    Below are the areas covered for each company in the market:

    • Company Overview
    • Business Strategy
    • Key Product Offerings
    • Financial Performance
    • Key Performance Indicators
    • Risk Analysis
    • Recent Development
    • Regional Presence
    • SWOT Analysis

Recent Developments

  • In August 2025, Mission Bio declared that it had successfully finished the equity financing to advance single-cell tri-omics capabilities and clinical applications across Cancer, led by Ally Bridge Group.
  • In January 2025, Illumina announced significant advancements to its NovaSeq X Series, including the launch of a single-flow-cell system, which is a powerful software upgrade, and new 100-cycle and 200-cycle kits, thereby enhancing the platform’s multiomic capabilities.
  • Report ID: 2666
  • Published Date: Sep 05, 2025
  • Report Format: PDF, PPT
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Frequently Asked Questions (FAQ)

In the year 2025, the industry size of the single cell genome sequencing market was over USD 3.6 billion.

The market size for the single cell genome sequencing market is projected to reach USD 21.2 billion by the end of 2035, expanding at a CAGR of 16.5% during the forecast period, i.e., between 2026-2035.

The major players in the market are 10x Genomics, Inc., Becton, Dickinson and Company (BD), Illumina, Inc., Thermo Fisher Scientific Inc., QIAGEN N.V., Bio-Rad Laboratories, Inc., Pacific Biosciences (PacBio), and others.

In terms of type, the instruments segment is anticipated to garner the largest market share of 59.5% by 2035 and display lucrative growth opportunities during 2026-2035.

North America is projected to hold the largest market share of 35.6% by the end of 2035 and provide more business opportunities in the future.
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