Global Market Size, Forecast, and Trend Highlights Over 2025-2037
Plant-based API Market size was over USD 34.4 billion in 2024 and is estimated to reach USD 74.9 billion by the end of 2037, expanding at a CAGR of 6.7% during the forecast timeline, i.e., 2025-2037. In 2025, the industry size of plant-based API is evaluated at USD 36.7 billion.
Shifting consumer preferences toward sustainable and environmental benefits is inflating demand in the market. These alternatives are designed to fulfill the rising need for chronic disease management efficiently while eliminating the need for animal-derived compounds. Moreover, the efforts to maintain transparency and ethical practice during drug development have propelled the production of these vegan and clean-label pharmaceutical products. According to an NLM article published in November 2022, the trade value of worldwide medicinal plants and their derivatives is expected to gain USD 50.0 trillion by 2050. It further classified the category into medicines, herbal medical products, botanicals, and natural health products.
Furthermore, the market is gradually gaining traction with the expanding exposure of the associated materials. According to a Research Nester projection, the active pharmaceutical ingredient industry was valued at USD 265.8 billion in 2024 and is poised to attain USD 557.6 billion by the end of 2037. In addition, the emerging landscape of biologics, where naturally extracted APIs are heavily used, is resulting in heightened engagement of this element. Thus, the deliberate evolution of this segment is evidence of driving growth in this sector. As per the report released by a division of the American Chemical Society, the global biologics merchandise is predicted to hold USD 569.7 billion by 2027, exhibiting a notable augmentation of 9.2%.
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Plant-based API Sector: Growth Drivers and Challenges
Growth Drivers
- Significant rise in biotechnology innovations: Increased R&D activities among private and public organizations to win the race of introducing novel bio-based therapeutics have boosted the plant-based API market. With groundbreaking extraction and processing methods, the biotech pioneers are establishing the foundation of plant cell culture, fermentation, and other efficient techniques. The individual creations are further igniting the adoption to produce more cost-effective and safer regimens. According to a study paper from the United Nations, the prefecture of biopharmaceuticals is estimated to gain USD 975.0 billion by 2030, augmenting a CAGR of 12.2%. It also mentioned that 57.2% of this category is comprised of biotechnology.
- Growing efforts to enlarge API production: The proven efficacy of products from the market is encouraging companies to leverage their capacities to foster mass fabrication. As eco-friendly regimens gain popularity across the world, a surge in plant-derived alternatives, in replacement of synthetic drugs, is dragging their focus on elevating their manufacturing capabilities. For instance, in January 2021, Asahi Kasei announced its plans to build the second plant for microcrystalline cellulose at its Mizushima Works site in Kurashiki. The upsurged demand for the company’s recently introduced Ceolus, due to its excellent tablet binding properties, led to this expansion.
Challenges
- Limited resources and marketing scope: Disruptions in supply chain of raw materials and essential components is a major setback in extending the market. Many environmental factors such as climate change and crop disease may affect the availability of required plants. In addition to this complexity of sourcing, the constrained commercialization of biologics creates volatility. As this application segment is a notable contributor to this sector’s prosperity, its limitation in market presence may impact the overall profit margin.
- Economic hurdle in adopting advancements: Besides the burden of expensive raw materials, the high cost of extraction and production may hinder participation in the market. Companies often refrain from adopting these environment-friendly active compounds due to its need for significant capital investment. Moreover, the additional expenses, associated with this business, makes it a skeptical choice for trading. Despite its popularity as an attractive alternative, the affordability issue raises an unavoidable hurdle in this field.
Plant-based API Market: Key Insights
Base Year |
2024 |
Forecast Year |
2025-2037 |
CAGR |
6.7% |
Base Year Market Size (2024) |
USD 34.4 billion |
Forecast Year Market Size (2037) |
USD 74.9 billion |
Regional Scope |
|
Plant-based API Segmentation
End use (Pharmaceuticals, Nutraceuticals, Herbal Based Industries)
In terms of end use, the pharmaceuticals segment is set to dominate plant-based API market share of around 66.4% by the end of 2037. The increasing research activities in the biopharmaceutical category to integrate a holistic approach by utilizing natural ingredients is impelling growth in this segment. The broad spectrum of offerings and heightened spending in the pharma industry presents a wider scope of application and utility for these components. An NLM data calculated the total pharmaceutical expenditure in the U.S., accounting for USD 576.9 billion in 2021, increased by 7.7% from 2020. It further stated that the overall spending on prescription remedies grew by 4-6% in 2022. In addition, the established maturation of bio-based innovations is fostering an adaptive marketplace.
Molecule Type (Alkaloids, Phenolic Acids, Terpenoids, Lignin & Stilbenes, Anthocyanin, Flavonoids)
Based on molecule type, the alkaloids segment is predicted to dominate the plant-based API market throughout the assessed timeframe. This compound is in high demand due to its well-versed utilization in curing pain, malaria, cancers, and poisoning. In addition, there is a wide spectrum of sources such as opium poppy, coffee & tea, cinchona tree, periwinkle plant, and belladonna to derive this material, offering easy accessibility. Further, the advantages of using alkaloids in treating chronic diseases make it the most preferable option. According to 2022 OEC data, the accumulated trade value of vegetable alkaloids was registered to be USD 2.3 billion, which grew by 20.0% from 2021. The traded elements of it were salts, ethers, esters, and other curative derivatives.
Our in-depth analysis of the global market includes the following segments:
End use |
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Molecule Type |
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Customize this ReportPlant-based API Industry - Regional Synopsis
North America Market Analysis
North America in plant-based API market is expected to hold over 36.3% revenue share by the end of 2037. Continuous research and development activities in the biopharma territory have positioned this region at the forefront of the global landscape. Its proprietorship is enriched by a robust R&D ecosystem and advanced laboratory infrastructure, supporting extensive fabrication. For instance, in January 2023, Agilent Technologies doubled its manufacturing capacity of therapeutic nucleic acids by investing USD 725.0 million to cope with the rising demand for such multifunctional APIs. In addition, the regulatory courage in promoting eco-friendly sourcing is playing a crucial role in maximum adoption.
The prime indication of heightening demand in the U.S. market is the increasing international purchases of such organic chemicals. According to the 2022 OEC report, this country imported vegetable alkaloids worth USD 420.0 million (18.0%), making it the largest importer of this substance in the world. Despite the previous crisis, a substantial urge for opioids is also signifying a healthy trading culture in the U.S. marketplace, attributable to the heavy usage in pain management and palliative care. Moreover, the changing demographics and treatment approaches of cancer care across the nation are driving the need for these phytochemicals, fueling growth in this sector.
The well-established healthcare network of Canada is feeding progress with a notable improvement in availability in the plant-based API market. As the herbal genre of therapeutics is predominantly becoming a mainstream pipeline of business, the inclusion of organic chemicals and nutraceuticals is dragging attention to the conventional medical system of the country. Furthermore, fastened licensing and legalization of medical cannabis are ensuring a steady propagation in this sector. As per the data from Health Canada, the number of individual registrations for personal and designated cultivation and utilization of cannabis rose by 6.0% from March to June 2024, reaching 16,609.
APAC Market Statistics
The Asia Pacific plant-based API market is projected to witness the fastest enlargement throughout the period between 2025 and 2037. The ancient presence of nutraceuticals in this region has empowered its propagation in this sector. The strong roots of traditional medicines in pharma powerhouses such as India, China, and Japan are now coupled with advanced synthesis and technology, delivering more effective and safer treatment solutions for various ailments. Inflating awareness among consumers is further inspiring domestic companies to be involved in this cohort. For instance, in October 2021, Sumitomo Chemical inaugurated a large-scale nucleic acid drug substance manufacturing facility at its Oita Prefecture, Japan. It raised the capacity of the company by 6 times.
India is home to one of the oldest medicinal practices, Ayurveda, which is still widely accepted across the country, preparing a large consumer base for the plant-based API market. The eventually prioritized health factors such as immune support and chronic disease management are presenting a potential marketplace for this sector with an ensured scope of profit. Its excellence in biotechnology is also a positive sign of advancement. According to an IBEF report, the biotechnology industry in India is poised to gain USD 150.0 billion in 2025. It also showed the possibility of this category to obtain USD 270-300 billion by 2030, while the biologics landscape is calculated to gain USD 12.0 billion in 2025.
China is augmenting the market with its proactive government-issued policies and grants by recognizing its potential to levitate national health outcomes. The impactful amalgamation of traditional medicine with modern practices helped the governing bodies regulate quality control, safety, and efficacy in the culture. Additionally, its exceptional manufacturing capabilities have outstretched its strings overseas. According to the OEC database, China was identified to be the largest exporter of vegetable alkaloids including opium, caffeine, rye ergot, ephedrine, nicotine, theophylline & aminophylline, cinchona, and quinine derives. It also highlighted the export value to be USD 482.0 million in 2022.
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Companies Dominating the Plant-based API Landscape
- Roquette Freres SA
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
- EVONIK Industries, AG
- Cargill, Inc.
- Novartis AG
- Sanofi SA
- Kothari Phytochemicals & Industries Ltd
- Centroflora Group
- Arboris, LLCs
- BASF SE
- GlaxoSmithKline, plc
Global leaders in the plant-based API market are solidifying their position through strategic initiatives, which are successfully ensuring the widespread of this methodology. Their effort to advance in new formulations and indications is encouraging other players to engage their resources. They are also investing in captivating novel synthesizing techniques to elevate the quality of the ingredients. For instance, in September 2024, Zydus Lifesciences acquired Sterling Biotech’s fermentation-based API business in a transaction of USD 9.5 million. The acquisition was intended to possess a complete array of offerings and a production site at Masa, Gujarat, strengthening its footprint in this sector. Such key players are:
In the News
- In April 2024, Roquette launched the LYCAGEL hydroxypropyl pea starch excipient range at Vitafoods Europe 2024 as an addition to its plant-based softgel. The new API pipeline broadened the company’s scope of globalization in the field of vegetarian and vegan supplements.
- In October 2023, Evonik announced the commercial launch of plant-based squalene, PhytoSquene for parenteral drug delivery applications. The functions of these adjuvant components aim to reduce dependency on animal-derived materials while maintaining quality and purity.
Author Credits: Radhika Pawar
- Report ID: 7136
- Published Date: Feb 17, 2025
- Report Format: PDF, PPT