Next-generation Sequencing Informatics Market Outlook:
Next-generation Sequencing Informatics Market size was USD 2.7 billion in 2024 and is expected to reach USD 8.3 billion by the end of 2034, growing at a CAGR of 12.9% during the forecast period, i.e., 2025-2034. In 2025, the industry size of next-generation sequencing informatics is assessed at USD 3.2 billion.
The worldwide patient pool in the market is gradually extending, attributed to a rise in cancer prevalence as well as chronic genetic diseases. In this regard, the World Health Organization (WHO) has estimated that there will be almost 35 million new cases of cancer yearly by the end of 2030, and the NIH indicated that approximately 450 million people suffer from rare genetic disorders globally. Besides, government-backed strategies, including the NIH’s All of Us Program, have successfully aimed to sequence 1.5 million genomes, along with the UK Biobank’s 500,000 whole-genome dataset, escalating the market adoption.
Moreover, in terms of economic indicators, the producer price index (PPI) increased to almost 6.5% year-over-year (YoY) for NGS informatics products, which has reflected surged expenses in sequencing consumables and bioinformatics software licensing. Likewise, the consumer price index (CPI) rose to 5.2% for clinical NGS services, highly fueling the need for prenatal and oncology evaluations. Meanwhile, the international trade in NGS-based products has reached USD 4.1 billion as of 2023, with Germany accounting for USD 920 million imports, and the U.S. accounting for USD 1.4 billion exports, which are leading the market flow. Therefore, all these factors are responsible for uplifting the market across nations.

Next-generation Sequencing Informatics Market - Growth Drivers and Challenges
Growth Drivers
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Reimbursement and government investment expansions: The existence of government healthcare programs is effectively driving the next-generation sequencing informatics industry through extended reimbursement policies. For instance, Medicare in the U.S. has reached USD 1.6 billion for NGS-based oncology evaluation as of 2023, initially due to suitable coverage for companion diagnostics, such as FoundationOne CDx, which has enhanced cancer treatment options. Besides, the FDA’s Breakthrough Device Designation has increased acceptance for liquid biopsy tests to diminish development duration by at least 45% and permit rapid commercialization.
- Reduced healthcare expenses through early diagnostics: The optimistic outlook of the next-generation sequencing informatics sector is that the product diminishes long-lasting healthcare expenses by ensuring early disorders identification. According to a clinical study published by the AHRQ in 2022, it has been demonstrated that NGS-guided cancer diagnostics constitute the ability to reduce hospitalization rates by almost 25%, thereby saving USD 4.2 billion in healthcare expenditure in the U.S. within two years. By recognizing high-risk patients at an early stage, hospitals tend to combat expensive late treatments, thus making NGS an affordable intervention.
- Cloud and AI-based bioinformatics scaling integration: Cloud and artificial intelligence (AI) computing are reducing analytical data expenses and time for the next-generation sequencing informatics market. In this regard, the All of Us Program initiated by the NIH has diminished genome processing costs from USD 1,500 to USD 250 by utilizing Google DeepVariant AI. Likewise, the NHS Genomic Medicine Service in the UK has divided processing times by AWS cloud infrastructure adoption. Therefore, these innovations have made the market scalable and allow population-level genomics programs to ensure market expansion.
Manufacturer Strategies Shaping NGS Informatics Market Expansion
Revenue Potential for NGS Informatics Manufacturers (2023–2025)
Company |
Strategy |
Revenue Impact (USD) |
Illumina |
DRAGEN AI adoption in EU/US clinics |
1.3 billion |
Thermo Fisher |
Oncomine Dx expansion in Asia-Pacific |
755 million |
BGI Group |
DNBSEQ-G400 launch in LATAM/EMEA |
450 million |
Oxford Nanopore |
Portable sequencers for rural diagnostics |
325 million |
Feasible Expansion Models Shaping the Future of the NGS Informatics Market
Feasibility Models for NGS Market Expansion (2022–2024)
Model |
Region |
Revenue Impact |
Hospital Partnerships |
India |
+14% Revenue Growth |
Public-Health Integration |
Brazil |
USD 160 million Annual Revenue |
Cloud-Based Scaling |
U.S. |
32.5% Cost Reduction |
Challenges
- Gaps in compensation and expenses: The aspect of high expenditure in the market has created several integration risks, especially in government-aided healthcare systems. For instance, Medicaid in the U.S. only covers 37% of NGS-based evaluations, owing to its average pricing policy, including USD 2,550 per test, which leaves patients without suitable accessibility. Likewise, the IQWiG in Germany has imposed stringent price caps on NGS-based products as of 2023, lowering manufacturer profitability by 28% and not encouraging advancements. Besides, emerging economies are experiencing obstacles, thus negatively impacting the overall market.
- Complicated acceptances and administrative delays: The market is undergoing prolonged and unreliable regulatory pathways across global economies. For instance, the FDA’s 510(k) backlog deliberately halted almost 17.5% of the U.S. market releases as of 2024. These delays are usually intensified by diverse regional standards, such as Europe’s IVDR requires additional clinical proof in comparison to the U.S. frameworks. Besides, small-scale organizations that are devoid of appropriate resources for multi-country trials frequently abandon extension plans, thus causing a hindrance in the overall market.
Next-generation Sequencing Informatics Market Size and Forecast:
Report Attribute | Details |
---|---|
Base Year |
2024 |
Forecast Year |
2025-2037 |
CAGR |
12.9% |
Base Year Market Size (2024) |
USD 2.7 billion |
Forecast Year Market Size (2034) |
USD 8.3 billion |
Regional Scope |
|
Next-generation Sequencing Informatics Market Segmentation:
Product Segment Analysis
Based on the product, the sequencing platforms segment in the next-generation sequencing informatics market is projected to hold the largest share of 49.5% by the end of 2034. The segment’s growth is highly driven by extended clinical applications and technological progressions. The introduction of ultra-high-throughput systems, including Illumina's NovaSeq X, which ensures 55% rapid sequencing at USD 225 per genome, is escalating the implementation. This is suitable especially in large-scale genomic strategies, such as the All of Us Program of the NIH, which is projected to effectively target 1.1 million genomes by the end of 2026.
Application Segment Analysis
Based on the application, the oncology diagnostics segment in the next-generation sequencing informatics market is expected to hold the second-largest share of 38.7% during the forecast duration. The segment’s upliftment is attributed to a surge in the international cancer burden as well as precision in medicines. In this regard, the WHO has indicated that there will be 35 million yearly cancer cases by the end of 2030, based on which NGS-specific liquid biopsies are emerging as the standard for 75% of innovative solid tumors in developed nations. Besides, cost-effectiveness and administrative approvals are other key drivers that are responsible for positively impacting the overall segment.
End user Segment Analysis
Based on the end user, the pharma and biotech companies segment in the next-generation sequencing informatics market is anticipated to hold the third-largest market share of 28.6% by the end of the forecast timeline. The segment’s development is effectively driven by precision medicine strategies, along with the aspect of drug development. In addition, the FDA’s 90% acceptance rate as of 2023, followed by the USD 4.8 billion NIH funding, particularly for biomarker discovery, and almost 45% reduction in expenses for target recognition, are other drivers, positively fueling the segment. Besides, Novartis and Roche are the topmost adopters, which denotes a positive outlook for the overall segment in the market.
Our in-depth analysis of the global market includes the following segments:
Segment |
Subsegments |
Product |
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Application |
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End user |
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Workflow |
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Delivery Mode |
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Next-generation Sequencing Informatics Market - Regional Analysis
North America Market Insights
North America in the next-generation sequencing informatics industry is considered the dominant region, with an expected highest share of 45.1% by the end of 2034. The market’s growth in the region is highly fueled by effective government-based funding as well as the presence of strong healthcare facilities. Additionally, the NIH’s USD 5.5 billion yearly provision for genomic research budget and Medicare’s expansion for NGS coverage, currently reimbursing at least 80% of oncology tests, are also suitable for uplifting the market in the region. Besides, liquid biopsy integration and AI-based NGS platforms are other notable trends that are positively impacting the market in the overall region.
The next-generation sequencing informatics sector in the U.S. is significantly growing, accounting for almost 95% of the region’s market, attributed to the All of Us Program initiated by the NIH, along with the USD 1.3 billion expenditure through Medicaid NGS. Besides, the FDA has successfully approved 17 AI-NGS tools as of 2023, diminishing analysis expenses by 42%. Meanwhile, Medicare effectively covers FoundationOne CDx, but state-based Medicaid barriers leave an estimated 16 million underserved patients. The AHRQ data has revealed that NGS reduces cancer expenses by USD 3.9 billion through early detection, thus denoting a positive impact on the market in the country.
The next-generation sequencing informatics market in Canada is also growing at a rate of 10.5%, which is generously supported by the USD 420 million genomics 2030 strategy. Ontario is deliberately leading with 200,150 NGS-based patients, but PHAC has reported that almost 35% of oncologists are devoid of training. Besides, Health Canada has rapidly approved 12 NGS panels in 2023, even though import expenses remain 35% above U.S. levels. Meanwhile, BC Cancer Agency’s NGS program has diminished the wait timeline by 60%, thereby suitable for market;s development in the country.
North America's NGS Informatics Trade & Supply Chain Facilities (2022–2025)
Facility Type |
Country |
Key Facilities (2022–2025) |
Manufacturing Plants |
U.S. |
Illumina's San Diego HQ (2022: USD 215 million expansion for NovaSeq X production) |
Canada |
Roche Diagnostics' Mississauga facility (2023: USD 158 million upgrade for NGS reagent production) |
|
Import Hubs |
U.S. |
Port of Los Angeles (2024: 40% of NGS chip imports from China) |
Canada |
Port of Vancouver (2023: USD 55 million NGS equipment imports from Germany) |
|
R&D Centers |
U.S. |
NIH-funded Broad Institute (2025: USD 125 million for AI-NGS integration) |
Canada |
Genome Quebec (2024: USD 82 million for pan-Canadian NGS data standardization) |
|
Tax Incentive Zones |
U.S. |
Texas Medical Center (2023: 15.5% tax rebate for NGS startups) |
Canada |
Montreal Biotech Park (2022: 20.5% R&D tax credit for NGS software firms) |
APAC Market Insights
Asia Pacific in the next-generation sequencing informatics market is considered the fastest-growing region, with a share of 20.3% and a growth rate of 15.2% between 2025 and 2034, which is highly attributed to government-based precision medicine, along with increasing cancer prevalence initiatives. China is dominating the region, driven by NMPA’s acceptance of more than 19 NGS panels and USD 2.5 billion yearly genomics funding. This is effectively followed by a surge in India, which is backed by administrative policies since 2024. Besides, South Korea is also leading in the AI-NGS incorporation, with almost 82% of tertiary hospitals utilizing AI-powered variant callers, thus suitable for the market growth.
The market in China is projected to garner at least 46% of the region’s share by the end of 2034, which is effectively fueled by fast clinical implementation and strong government support. The NMPA has accepted over 22 NGS panels as of 2023, which include BGI’s MGISEQ-2000 for oncology. Besides, domestically funded genomics programs have allocated USD 2.2 billion every year by targeting 13 million sequenced genomes by the end of 2030. However, localized data laws have raised compliance expenses by an estimated 32.5%, and at least 75% of sequencers are imported from Germany and the U.S., developing vulnerabilities in the supply chain.
The next-generation sequencing informatics market in India is increasing with an 18.5% growth rate, attributed to Ayushman Bharat’s 2024 coverage extension for almost 500,200 patients. As per an article published by the ICMR, it has been reported that 2.6 million patients are NGS-eligible every year, but only 90% are unable to gain accessibility, owing to high expenses, amounting to approximately ₹50,500 per test. Besides, the 2023 National Biopharma Mission made an investment of USD 260 million in localized NGS production to diminish reagent import reliance by 22%. Meanwhile, Tata Medical Center’s AI-NGS program reduced turnaround duration by 45%, thus suitable for market upliftment in the country.
APAC Government Investments/Policies in NGS Informatics (2022–2025)
Country |
Initiative/Policy |
Funding/Scope (2022–2025) |
Launch Year |
Australia |
National Genomics Health Mission |
AUD 550 million for 520,000 genomes sequenced |
2022 |
Medicare rebate for NGS oncology tests |
Covers 82% of NGS costs for 50,200 patients annually |
2023 |
|
Malaysia |
Bioeconomy Corp NGS Reagent Production Plan |
MYR 210 million for local reagent manufacturing |
2024 |
MyGenome Program (Public-Private Partnership) |
100,500 genomes sequenced by 2025 |
2023 |
|
South Korea |
AI-NGS Integration Initiative (Ministry of Science) |
KRW 330 billion (~USD 235 million) for AI-based variant calling |
2022 |
National Rare Disease NGS Coverage Expansion |
95.5% reimbursement for 30,150 patients |
2024 |
Sources: Australian Government, Services Australia, Bioeconomy Corp, Ministry of Health MY, MSIT Korea, Korea Health Industry
Europe Market Insights
Europe in the next-generation sequencing informatics market is expected to hold a considerable share of 28.2% by the end of the forecast duration, along with a 10.7% growth rate. The market’s upliftment in the region is highly fueled by an upsurge in the cancer occurrence, as well as Europe-based genomic strategies. The regional Health Data Space (HDS) generously allocated €2.8 billion by the end of 2027, particularly for NGS interoperability. Germany is leading with NGS expenditure as of 2024, along with an increase in the yearly demand growth. This is followed by the UK, with the availability of administrative-based Genomic Medicine Services, all of which aim to bolster the market in the region.
The market in Germany is dominating the region’s market, with a 30.5% revenue share, which is highly fueled by the €4.7 billion yearly government expenditure, along with universal NGS coverage, particularly for oncology. Besides, the German Medical Association has successfully mandated NGS for metastatic cancers, thereby bolstering the implementation rate by at least 18.5% yearly. Meanwhile, partnerships, such as Siemens Healthineers’ €1.2 billion collaboration with Illumina, have escalated the AI-NGS incorporation, thus creating an optimistic outlook for the overall market in the country.
The next-generation sequencing informatics market in the UK is expected to hold approximately 26.5% of the region’s market, which is highly driven by the NHS England’s Genomic Medicine Service, covering 80,500 tests every year. Besides, almost 9% of the NHS budget, accounting for £1.4 billion funds for NGS, with the Genome UK 2025 effectively targeting 500,100 sequenced genomes. Meanwhile, the 100,200 Genomes Project diminished chronic disorder diagnosis duration by 55%. In addition, private sector investments are also driving the market demand, but Brexit-based reagent delays have enhanced costs by 25%, thereby suitable for market upliftment.

Key Next-generation Sequencing Informatics Market Players:
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
The next-generation sequencing informatics sector is severely united with the presence of organizations, including Illumina, accounting for 35.8% of the market share, along with Thermo Fisher, accounting for 22.5%, collectively dominating through proprietary platforms. Additionally, Roche constitutes 13.5% and BGI caters to 9.5% of the overall market share, and they jointly compete on total expenses. Besides, localized manufacturing, portable sequencing, and AI implementation are tactical strategies that are responsible for boosting the market internationally.
Here is a list of key players operating in the global market:
Company Name |
Country |
Industry Focus |
Illumina |
U.S. |
Sequencing platforms (NovaSeq X), DRAGEN AI analysis software |
Thermo Fisher Scientific |
U.S. |
Ion GeneStudio S5 systems, Oncomine Dx panels |
Roche Diagnostics |
Switzerland |
AVENIO NGS oncology kits, cloud-based analysis tools |
BGI Group |
China |
DNBSEQ platforms, low-cost sequencing for emerging markets |
Oxford Nanopore Technologies |
UK |
Portable sequencers (MinION), real-time DNA/RNA analysis |
QIAGEN |
Germany |
NGS sample prep kits (QIAseq), clinical interpretation software |
Agilent Technologies |
U.S. |
SureSelect target enrichment, NGS automation solutions |
Pacific Biosciences (PacBio) |
U.S. |
HiFi long-read sequencing (Sequel IIe) |
PerkinElmer |
U.S. |
NGS automation (Chemagic), reproductive health testing |
Fabric Genomics |
U.S. |
AI-powered clinical interpretation (Fabric Enterprise) |
DNAnexus |
U.S. |
Cloud-based NGS data management (FDA-cleared platform) |
Sophia Genetics |
Switzerland |
AI-driven variant calling (SOPHiA DDM) for oncology |
Macrogen |
South Korea |
Whole-genome sequencing services, focus on Asian populations |
MedGenome |
India |
Affordable NGS for infectious diseases and oncology (Labs in India/Singapore) |
Bio-Rad Laboratories |
U.S. |
ddPCR-based NGS validation, single-cell sequencing |
Sources: Illumina, Thermo Fisher, Roche, BGI, Nanopore, QIAGEN, Agilent, PacBio, PerkinElmer, Fabric Genomics, DNAnexus, SOPHiA GENETICS, Macrogen, MedGenome, Bio-Rad, Sysmex, Hitachi HT, Takara Bio, Shimadzu, Miroculus
Below are the areas covered for each company in the market:
Recent Developments
- In May 2024, Illumina unveiled the NovaSeq X Plus, which is a high-throughput sequencer with USD 240 per genome expense that effectively targets population-based scale projects, such as the NIH’s All of Us Program.
- In April 2024, Thermo Fisher Scientific successfully extended its Oncomine Dx Precision Medicine Suite, with 52 latest biomarkers, by achieving acceptance by the FDA for breast and lung cancer diagnostics.
- Report ID: 7939
- Published Date: Jul 25, 2025
- Report Format: PDF, PPT
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