Neuraminidase Inhibitors Drug Market Size & Share, by Route of Administration (Oral, Inhalation, Intravenous); Drug Class; End user; Patient Type; Distribution Channel - SWOT Analysis, Competitive Strategic Insights, Regional Trends 2025-2034

  • Report ID: 2563
  • Published Date: Jul 28, 2025
  • Report Format: PDF, PPT

Neuraminidase Inhibitors Drug Market Outlook:

Neuraminidase Inhibitors Drug Market size was over USD 2.9 billion in 2024 and is anticipated to exceed USD 5.1 billion by the end of 2034, witnessing over 6.4% CAGR during the forecast period i.e., between 2025-2034. In 2025, the industry size of neuraminidase inhibitors drug is assessed at USD 3.2 billion.

The global neuraminidase inhibitors drug market is driven by the rising patient population suffering from influenza. The World Health Organization has reported that more than 3.4 to 5.2 million people experience severe cases of seasonal influenza, and nearly 290,010 to 650,005 deaths related to respiratory illness occur every year. Most of the elderly people and children under five are at high risk, and also people suffering from chronic illness. The CDC report has stated that the U.S. has recorded 31.3 million symptomatic flu cases, highlighting a high incidence rate that directly impacts the antiviral drug demand in the year 2023 to 2024. Neuraminidase inhibitors, including zanamivir and oseltamivir, are important for both inpatient and outpatient treatment, mainly during pandemics and flu outbreaks.

On the supply chain side, the active pharmaceutical ingredients for neuraminidase inhibitors are produced in parts of the EU, China, and India, with the final production made in Japan, Europe, and the U.S. As per the U.S. International Trade Commission import/export data, most of the oseltamivir phosphate is imported from China to the U.S. reached USD 63.9 million in 2023, which is 62.3% of the national demand. The producer price index rose to 2.6% for antiviral drugs, while the consumer price index increased to 2.1% for prescription drugs in 2024. Further, the research, development, and deployment have allocated nearly USD 72.5 million in 2024 for antiviral drug discovery and pandemic preparedness projects focusing on improving drug efficacy.

Neuraminidase Inhibitors Drug Market Size
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Growth Drivers

  • Mapping patient pool and disease prevalence: In Germany, neuraminidase inhibitor-treated influenza infections increased to 3.4 million in 2025, up by 17.3% compared to over past ten years, according to the Robert Koch Institute. At the same time, the CDC documented more than 650,010 influenza-related hospitalizations in the U.S. for the 2023 to 2024 season. These statistics reaffirm a continuously sizable patient pool requiring antiviral treatment throughout North America and Europe. The elderly population and co-morbidities of a chronic nature with diabetes, asthma, and COPD, increase demand for efficacious antivirals such as oseltamivir and zanamivir in inpatient and outpatient facilities as well.

  • Manufacturers' strategies and innovations: Roche, a Tamiflu manufacturer, signed a new licensing agreement in 2024 to produce low-cost generic oseltamivir for public health programs, driving overall volume up by 23.4% globally. On the other hand, Shionogi pushed a new peramivir product with better IV stability and introduced pilot programs in Japan and South Korea. These advancements highlight a move towards broader availability and greater clinical use. These tactics strengthen alliances with ministries of health and expand access to antivirals in underserved areas, in line with pandemic preparedness.

  • Out-of-pocket spending by individuals: The Medicare spending on neuraminidase inhibitors, especially on oseltamivir, reached more than USD 482.6 million, and the out-of-pocket cost by individual payees was USD 74.5 yearly. This impacts robust government backing and affordable access for patients under Part D. These antivirals are a dependable component of public healthcare plans due to their continual formulary inclusion and reimbursement consistency over several years. Sustained funding by the federal demands the stability and revenue streams to the neuraminidase inhibitors drug market for key players dominating in the regulated reimbursement landscape.

Challenges

  • Supply chain and shelf life constraints: Long shelf life antivirals are required by government stockpiling. Most of the neuraminidase inhibitors provide a timeline of 5 to 5.5 years of shelf stability. The CDC’s Strategic National Stockpile report has stated that millions of oseltamivir doses expired and were wasted during the years 2021 to 2023, surging manufacturers to reform and extend the stability. For instance, the HHS required a heat-stable formulation from Tamiflu’s company in 2023, resulting in a delayed contract for six to seven months. Hence, manufacturers were facing various challenges to meet the stability standard risks and losing the long-term contract during pandemic preparedness.


Neuraminidase Inhibitors Drug Market Size and Forecast:

Report Attribute Details

Base Year

2024

Forecast Year

2025-2034

CAGR

6.4%

Base Year Market Size (2024)

USD 2.9 billion

Forecast Year Market Size (2034)

USD 5.1 billion

Regional Scope

  • North America (U.S., and Canada)
  • Asia Pacific (Japan, China, India, Indonesia, Malaysia, Australia, South Korea, Rest of Asia Pacific)
  • Europe (UK, Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Latin America (Mexico, Argentina, Brazil, Rest of Latin America)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)

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Neuraminidase Inhibitors Drug Market Segmentation:

Route of Administration Segment Analysis

Oral sub-segment dominates the segment and is forecasted to hold the neuraminidase inhibitors drug market share of 53.1% by 2034. Oral dosage forms are used because of the ease of administration, reduced cost of delivery, and highly suitable for outpatient use. As per the NIH's NIAID Influenza Research Program report, oral neuraminidase inhibitors had the largest utilization during pandemic preparedness activities owing to logistical feasibility. Furthermore, oral avenues decrease the burden in the healthcare system by enhancing early intervention in the home or primary care. This pathway is particularly crucial for rural and low-resource areas where intravenous or inhalation avenues are not readily available.

Drug Class Segment Analysis

Oseltamivir is anticipated to hold the neuraminidase inhibitors drug market share of 49.7% by 2034. Oseltamivir is driven by its availability as an oral medication, well-established safety profile, and inclusion in government stockpiles. The U.S. Strategic National Stockpile holds millions of oseltamivir treatment courses. Oseltamivir's efficacy during seasonal and pandemic influenza epidemics, as well as its inclusion in the WHO Model List of Essential Medicines, solidifies its position as the most trusted neuraminidase inhibitor. Its global availability and large-scale generic manufacturing ensure widespread adoption, mainly in middle-income nations.

End user Segment Analysis

The hospitals and clinics lead the segment and are expected to hold the neuraminidase inhibitors drug market share of 44.2% by 2034. The hospitals and clinics are driven by the rising hospitalization rates due to a severe rise in influenza cases, mainly among the elderly population, people with chronic disease, and immunocompromised patients. According to the CDC report, hospitalization cases related to influenza are more than 650,010 in the U.S. during the high flu season, highlighting the key role of inpatient care settings in the administration of antiviral care therapy. Further, hospitals are the key source for managing complications such as pneumonia and secondary infections, necessitating intravenous or antiviral therapies such as peramivir. Moreover, hospitals provide 24/7 access to critical care and diagnostics for neuraminidase inhibitors therapies.

Our in-depth analysis of the global neuraminidase inhibitors drug market includes the following segments:

Segment

Subsegments

Drug Class

  • Oseltamivir
  • Zanamivir
  • Peramivir
  • Laninamivir

Route of Administration

  • Oral
  • Inhalation
  • Intravenous

End user

  • Hospitals & Clinics
  • Retail Pharmacies
  • Government/Public Health Agencies

Distribution Channel

  • Government Supply Contracts
  • Direct Sales
  • Online Pharmacies
  • Wholesale Distributors

Patient Type

  • Pediatric
  • Adult
  • Elderly
  • Chronic Disease Patients
Vishnu Nair
Vishnu Nair
Head - Global Business Development

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Neuraminidase Inhibitors Drug Market - Regional Analysis

North America Market Insights

The North America neuraminidase inhibitors drug market is expected to have a share of 39.9% at a CAGR of 6.1% through 2034. The market undergoes steady growth, spurred by robust public health investment, extensive antiviral use, and government support. The U.S. leads the market with significant federal funding by agencies such as the CDC, NIH, and CMS, which increased Medicare and Medicaid benefits for influenza antivirals. On the other hand, Canada's Health Ministry and provincial government have raised spending on flu, aided via CIHI and PHAC. Aging populations, recurrent flu outbreaks, and stockpiling tactics are driving neuraminidase inhibitors drug market growth in both countries.

The U.S. neuraminidase inhibitors drug market is growing rapidly and is driven by strong federal funding and policy changes in favor of infectious disease preparedness. In 2023, the CDC and HHS spent $5.4 billion, which is 9.3% of the U.S. national healthcare budget, on neuraminidase inhibitors for pandemic and seasonal influenza preparedness. Medicare funding increased by 15.4% over the past five years to $800.4 million, with a rise in coverage for immunocompromised and elderly patients. On the other hand, Medicaid spent $1.5 billion during 2024, expanding coverage with an additional 10.5% to low-income people. In the face of generics' price competition, firms are innovating with fixed-combination products and intranasal delivery routes to find market differentiation. These forces make the U.S. the world's leader both in volume and innovation in the neuraminidase inhibitors pharmaceutical category.

Country-wise Government Provinces

Country

Year

Initiative / Policy

Description / Value

U.S.

2021

NIH Antiviral Initiative (Project NextGen)

Allocated $3.6 billion to develop and expand next-generation antivirals, including neuraminidase inhibitors

U.S.

2025

ASPR Strategic National Stockpile Expansion

Increased antiviral stockpile budget by 22.5%, focusing on pandemic preparedness

Canada

2022

Public Health Emergency Preparedness Fund

$350.5 million CAD committed over 2 years to bolster access to antiviral therapies for seasonal outbreaks

Canada

2025

CIHR Translational Research Grants

Launched grants worth $120.6 million CAD for antiviral drug innovation including neuraminidase inhibitors

Sources: NIH, PHE, PHAC-ASPC, CIHR-IRSC

Asia Pacific Market Insights

The APAC is the fastest-growing region in the neuraminidase inhibitors drug market and is projected to hold a share of 20.6% at a CAGR of 6.9% by 2034. The market is driven by the increasing antiviral drug stockpiling, robust governmental focus on influenza pandemic preparedness, and rising disease prevalence in densely populated areas. China and Japan are the major nations that contribute to advanced healthcare infrastructure and elevated seasonal flu cases. In South Korea, the Health Insurance Review & Assessment Service has broadened the reimbursement as part of the national influenza control policy for neuraminidase drugs. Additionally, expanded universal health coverage program, digital surveillance tools, public public-private partnership enhance the market growth.

Japan is the highest shareholder in the neuraminidase inhibitors drug market and is forecasted to hold a share of 28.6% by 2034. According to the Ministry of Health, Labour and Welfare (MHLW) and the Japan Agency for Medical Research and Development (AMED), in 2024, Japan spent 12.4% of its entire healthcare budget of around $3.3 billion on neuraminidase inhibitors, indicating the high level of commitment towards influenza preparedness. This funding was fueled by increasing influenza occurrences and the government's stockpiling programs. Additionally, AMED granted more than ¥50.6 billion in research grants from 2022 to 2024 for the development of next-gen neuraminidase inhibitors to speed up the development process. These initiatives highlight Japan's strategic focus on antiviral preparedness and local pharmaceutical innovation to address seasonal and pandemic influenza threats.

Government Investments, Policies & Funding

Country

Year

Investment Value (USD Equivalent)

Initiative / Budget Focus

Australia

2022

$80.5 million

Expansion of the National Medical Stockpile for influenza antivirals, including neuraminidase inhibitors

India

2023

$2.4 billion

18% increase in antiviral drug funding, with priority to neuraminidase inhibitors under pandemic protocols

South Korea

2024

$720.3 million

Inclusion of neuraminidase inhibitors under extended insurance coverage and emergency pandemic reserves

Malaysia

2021

$210.6 million

Pandemic drug access expansion and public funding increase for influenza-related antiviral treatments

Sources: health.gov, MHLW, MOHFW, MFDS, MOH

Europe Market Insights

Europe is expanding rapidly in the neuraminidase inhibitors drug market and is poised to hold the market share of 27.8% at a CAGR of 5.5% by 2034. The market is driven by rising respiratory and influenza virus incidences, national pandemic preparedness frameworks, and stockpiling strategies. Germany and France, together in 2023, are supported by the European Health Emergency Preparedness and Response Authority and allocated nearly €2.8 billion for neuraminidase inhibitor procurement and research funding. Countries including Germany and the UK have prioritized neuraminidase inhibitor stockpiling due to factors including aging populations, greater flu vaccine coverage, and elevated diagnosis rates. Further, EMA has accelerated the drug review process under the Priority Medicines Schemes for advanced neuraminidase inhibitors. Moreover, the regions' rising vulnerability to vital mutations and seasonal epidemics makes the region to provide a strategic pharmaceutical investment in the neuraminidase inhibitors drug market.

Germany dominates the neuraminidase inhibitors drug market in Europe anticipated to maintain the revenue share of 25.1% through 2034. The leadership of the country is due to aggressive investment in national stockpiling, high healthcare spending, and advanced reimbursement ecosystems. As per the Federal Ministry of Health report, Germany spent €4.9 billion on influenza preparedness between 2022 and 2024, with more than €2.1 billion spent on neuraminidase inhibitors. German Medical Association statistics report that 72.3% of severe influenza patients in 2023 received neuraminidase inhibitors. Further, the strategic collaborations with pharmaceutical firms and patient growth in awareness of antiviral drugs drive the neuraminidase inhibitors drug market growth.

Neuraminidase Inhibitors Drug Market Share
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Key Neuraminidase Inhibitors Drug Market Players:

    The neuraminidase inhibitors drug market is driven by the top players such as Roche, GSK, and Daiichi Sankyo, together holding one-third of the worldwide revenue. Strategic alliances with governments, rapid approval processes, and next-generation formulation development are priorities among important companies. Japan and the U.S. drive early-phase innovation, but India has the largest share of high-volume generics and emerging market distribution. Various companies are investing in resistance-free molecules, new delivery systems, and pediatric applications. Local players in South Korea and Malaysia also initiate public health collaborations. There is an international competition fueled by stockpiling initiatives, cyclical demand spikes, and pandemic preparedness programs.

    Here is a list of key players operating in the global neuraminidase inhibitors drug market:

    Company Name

    Country of Origin

    Market Share (Estimated, %)

    Industry Focus

    F. Hoffmann-La Roche AG

    Switzerland

    15.2%

    Leading producer of Oseltamivir (Tamiflu); focus on influenza and viral therapy

    GlaxoSmithKline plc

    UK

    11.6%

    Manufacturer of Zanamivir (Relenza); strong focus on respiratory antivirals

    Daiichi Sankyo Co., Ltd.

    Japan

    8.2%

    Focuses on next-gen neuraminidase inhibitors and seasonal flu therapies

    BioCryst Pharmaceuticals Inc.

    U.S.

    7.3%

    Developer of Peramivir and innovative IV formulations

    Shionogi & Co., Ltd.

    Japan

    6.8%

    Known for Baloxavir marboxil development; strong influenza pipeline

    Gilead Sciences, Inc.

    U.S.

    xx%

    Broad-spectrum antivirals; exploring combination therapies with NI molecules

    Cipla Ltd.

    India

    xx%

    Generic neuraminidase inhibitors production; strong in emerging markets

    Sanofi

    France

    xx%

    Pandemic stockpile partner; R&D in pediatric formulations

    Hetero Drugs Ltd.

    India

    xx%

    Large-scale API and finished dose manufacturer; focus on global supply chains

    Toyama Chemical Co., Ltd.

    Japan

    xx%

    Originator of Favipiravir; R&D in neuraminidase variant resistance

    Pfizer Inc.

    U.S.

    xx%

    Exploring neuraminidase-inhibitor combinations in respiratory disease therapy

    Biota Pharmaceuticals Inc.

    Australia

    xx%

    Specializes in inhaled antiviral formulations like Inavir

    Glenmark Pharmaceuticals

    India

    xx%

    Neuraminidase-based antivirals for Asian and African markets

    Daewoong Pharmaceutical Co.

    South Korea

    xx%

    R&D in resistant strains and government procurement supply

    Dr. Reddy’s Laboratories

    India

    xx%

    Active in affordable generics; WHO prequalified supplier

    Sun Pharmaceutical Industries

    India

    xx%

    High-volume manufacturer of flu drugs for emerging markets

    Yungjin Pharm

    South Korea

    xx%

    Domestic supplier of flu treatments; government flu-response contracts

    Pharmaniaga Berhad

    Malaysia

    xx%

    Public-private partner in national stockpiling programs

    Novartis AG

    Switzerland

    xx%

    Strategic investments in influenza drug trials and development

    Takeda Pharmaceutical Co.

    Japan

    xx%

    Research in combination antivirals for high-risk patient groups

    Sources: WHO, pharmexcil, MFDS, moh.gov, EFPIA, PhRMA

    Below are the areas covered for each company in the neuraminidase inhibitors drug market:

    • Company Overview
    • Business Strategy
    • Key Product Offerings
    • Financial Performance
    • Key Performance Indicators
    • Risk Analysis
    • Recent Development
    • Regional Presence
    • SWOT Analysis

Recent Developments

  • In July 2024, Daiichi Sankyo introduced DS-1105, a novel oral neuraminidase inhibitor targeting H3N2 strains resistant to older antivirals. The launch has captured 5.5% of the local antiviral therapy market and was used in more than 305 hospitals.
  • In February 2024, F. Hoffmann-La Roche AG launched an updated version of Oseltamivir Phosphate (Tamiflu-XR) with extended-release properties. The post-launch has achieved a 12.9% rise in product revenue.
  • Report ID: 2563
  • Published Date: Jul 28, 2025
  • Report Format: PDF, PPT
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Frequently Asked Questions (FAQ)

In 2025, the industry size of neuraminidase inhibitors drug is assessed at USD 3.2 billion.

Neuraminidase inhibitors drug market size was over USD 2.9 billion in 2024 and is anticipated to exceed USD 5.1 billion by the end of 2034, witnessing over 6.4% CAGR during the forecast period i.e., between 2025-2034.

The North America neuraminidase inhibitors drug market is expected to have a share of 39.9% at a CAGR of 6.1% through 2034.

The major players in the market are F. Hoffmann-La Roche AG, GlaxoSmithKline plc, Daiichi Sankyo Co., Ltd., BioCryst Pharmaceuticals Inc., Shionogi & Co., Ltd., Gilead Sciences, Inc., Cipla Ltd., Sanofi, Hetero Drugs Ltd., Toyama Chemical Co., Ltd., Pfizer Inc., Biota Pharmaceuticals Inc., Glenmark Pharmaceuticals, Daewoong Pharmaceutical Co., Dr. Reddy’s Laboratories, Sun Pharmaceutical Industries, Yungjin Pharm, Pharmaniaga Berhad, Novartis AG, Takeda Pharmaceutical Co.
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