Methotrexate Drugs Market Analysis

  • Report ID: 2738
  • Published Date: Sep 25, 2025
  • Report Format: PDF, PPT

Methotrexate Drugs Market Segmentation:

Distribution Channel Segment Analysis

Based on the distribution channel, the hospital pharmacies segment in the methotrexate drugs market is anticipated to account for 60.8% of the market share by the end of 2035. The segment’s growth is highly attributed to clinical demands for managing high-dose methotrexate, which is suitable for catering to chemotherapy regimens for specific cancers, such as lymphoma and lymphoblastic leukemia. This particular treatment has been mandated for rigid inpatient monitoring for critical toxicity, including nephrotoxicity and myelosuppression. Besides, the increased administration for complicated biologic therapies, especially for autoimmune disorders, frequently monitored and initiated in hospitals and clinical centers, is also contributing towards the overall segment.

Route of Administration Segment Analysis

Based on the route of administration, the oral segment in the methotrexate drugs market is projected to account for the second-highest market share during the forecast period. The segment’s development is highly driven by the aspect of medication in a cost-effective and convenient way, along with the most commonly utilized administration form. In this regard, the September 2023 NLM article indicated that methotrexate drugs are administered either subcutaneously or orally in dosages of almost 30 mg per week, which is considered the most primary site of drug absorption, thus suitable for driving the segment’s exposure internationally.

Formulation Segment Analysis

Based on the formulation, the tablets segment in the methotrexate drugs market is expected to cater for the third-largest share by the end of the projected period. The segment’s growth is subject to optimizing patient care through digitalized record accessibility, ensuring communication support, and providing real-time monitoring. According to the January 2025 EMC Organization article, the suitable dosage for methotrexate is a 2.5 mg tablet, which results in increased growth of cancer cells. Additionally, with this dosage in the form of a tablet assists in treating different psoriasis cases and RA, thereby denoting an optimistic approach for the segment’s exposure in the market globally.

Our in-depth analysis of the market includes the following segments:

Segment

Subsegments

Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
    • Tablets
    • Injectable Solutions
  • Online Pharmacies

Route of Administration

  • Oral
  • Parenteral
    • Subcutaneous
    • Intramuscular
    • Intravenous

Formulation

  • Tablets
    • Branded
    • Generic
  • Injectable Solutions

Application

  • Rheumatoid Arthritis
  • Oncology
  • Psoriasis
  • Other Autoimmune Diseases

Drug Type

  • Branded
  • Generic

End user

  • Hospitals
  • Specialty Clinics
  • Home Healthcare

Browse key industry insights with market data tables & charts from the report:

Frequently Asked Questions (FAQ)

In the year 2025, the industry size of the methotrexate drugs market was over USD 633.7 million.

The market size for the methotrexate drugs market is projected to reach USD 871.2 million by the end of 2035 expanding at a CAGR of 3.6% during the forecast period i.e., between 2026-2035.

North America methotrexate drugs market will hold around 35.5% share by 2035, driven by rising surgical procedures and traffic-related injuries.

Key players in the market include Pfizer Inc., Azurity Pharmaceuticals, Inc., Cumberland Pharmaceuticals Inc., Teva Pharmaceuticals USA, Inc., Amneal Pharmaceuticals LLC, Sun Pharmaceutical Industries Ltd., Aurobindo Pharma Limited, Sandoz Inc, Hikma Pharmaceuticals PLC, Eisai Co., Ltd.
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