In Situ Hybridization Market size was over USD 1.82 billion in 2024 and is poised to reach USD 7.76 billion by the end of 2037, witnessing around 11.8% CAGR during the forecast period i.e., between 2025-2037. In the year 2025, the industry size of in situ hybridization is assessed at USD 1.99 billion. The reason behind the growth is due to the rising incidence of cancer across the globe. Fluorescence in situ hybridization also known as FISH scans cells for alterations in genes can aid in cancer diagnosis and can be used to track treatment response and illness remission. In 2040, there will likely be more than 28 million new instances of cancer worldwide.
The growing technological advancements in In-vitro diagnostics (IVD) are believed to fuel the market growth. For instance, Artificial intelligence (AI) technology integration in oncology-based in vitro diagnostic (IVD) technologies has the potential to significantly enhance healthcare decisions by identifying disease signatures that can aid in early detection and treatment, and by identifying central nervous system (CNS) cancers by predicting which therapy responses will be most successful using patient samples.
Growth Drivers
According to the World Health Organization (WHO), the number of individuals in the world who are 60 or older will increase to 2.1 billion by 2050.
Challenges
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Base Year |
2024 |
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Forecast Year |
2025-2037 |
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CAGR |
11.8% |
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Base Year Market Size (2024) |
USD 1.82 billion |
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Forecast Year Market Size (2037) |
USD 7.76 billion |
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Regional Scope |
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Technology (Fluorescent In Situ Hybridization (FISH), Chromogenic In Situ Hybridization (CISH))
The fluorescent In situ hybridization (FISH) segment in the in situ hybridization market is estimated to gain a robust revenue share of 55% in the coming years owing to the rising incidence of genetic diseases. It is expected that rising cases of stillbirths, and frequent miscarriages are all signs leading to a hereditary condition that is characterized by one or more anomalies in the genome is referred to as a genetic condition.
Lately, the majority of in situ hybridization procedures employ fluorescent probes which is a laboratory technique used to detect DNA sequences, and is applied to detect genetic abnormalities, and diagnose congenital diseases. For instance, in industrialized nations, genetic illnesses and congenital anomalies account for over 25% of pediatric hospital admissions, affect more than 4% of all live births, and account for roughly 49% of all infant fatalities.
Additionally, the chromogenic In situ hybridization (CISH) segment is anticipated to garner significant market share. Chromogenic in situ hybridization (CISH), is a cytogenetic method for determining gene amplification using a peroxidase-based chromogenic reaction that is growing in popularity as a useful, affordable, and legitimate alternative to fluorescent in situ hybridization when testing for gene alteration, particularly in centers that focus primarily on immunohistochemistry (IHC).
Probe (DNA, RNA)
The DNA segment in the in situ hybridization market is set to garner a notable share shortly. In situ hybridization uses many different kinds of probes; including a DNA probe that is a popular technique for mapping sequences to certain chromosomal regions, and can be used to hybridize to a sample's known target DNA or mRNA sequence. Besides this, the probes can be utilized to find the location of the mRNA and are used to enzymatically integrate nucleotides with amine modifications.
End-User (Research & Diagnostic Laboratories, CROs, Academic Institutes, Pharmaceutical & Biotechnological Companies)
The research & diagnostic laboratories segment in the in situ hybridization market is poised to garner a significant share by the year 2037. In situ, hybridization is a laboratory method for recognizing certain mRNA species within individual cells in tissue sections and is widely being utilized for scientific purposes, including clinical cytogenetics, gene mapping, tumor biology, and investigations of chromosome evolution.
Application (Cancer, Cytogenetics, Developmental Biology, Infectious Diseases, Neuroscience)
The cancer segment is anticipated to gain a notable market share during the forecast timeframe. In Situ, the Hybridization test is effective for detecting some forms of the disease and can provide information about the genetic makeup of cancer. Besides this, this method can more accurately predict the prognosis and course of specific cancers, such as leukemias, lymphomas, melanoma, bladder cancer, and others, and can be employed in research to identify other diseases, and lowering the risk of birth deformities through in vitro fertilization (IVF).
Our in-depth analysis of the global in situ hybridization market includes the following segments:
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North American Market Forecast
In situ hybridization market in North America is predicted to account for the largest share of 45% by 2037 impelled by the increasing spending in healthcare. This has led to the development of advanced diagnostic technologies including In Situ Hybridization which is expected to improve the accessibility to these services for people in the region. According to estimates, spending on health care in the United States increased by more than 2% in 2021 to around USD 4 trillion.
APAC Market Statistics
The APAC in situ hybridization market is estimated to be the second largest, during the forecast timeframe led by rising initiatives to improve the healthcare system. For instance, several efforts have been initiated by the government of India to increase access to healthcare such as Ayushman Bharat, which seeks to holistically treat health at primary, secondary, and tertiary levels and aims to meet the healthcare needs of more than 70% of people throughout their lifetime. As a result, there is a growing demand for diagnostic tools such as In situ hybridization as more people are likely to emphasize early diagnosis of several diseases.
Author Credits: Radhika Pawar
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