Histone Deacetylase Inhibitors Market Analysis

  • Report ID: 5349
  • Published Date: Nov 26, 2025
  • Report Format: PDF, PPT

Histone Deacetylase Inhibitors Market Segmentation:

Route of Administration Segment Analysis

The oral HDAC inhibitors segment in the histone deacetylase inhibitors market is estimated to hold 55.0% of the revenue share over the assessed timeline. The worldwide availability and acceptability of orally administrated medications are the major driving factors in this segment. These epigenetic agents have several potential benefits, including the seamless regulation of gene expression, a broad spectrum of applications, and patient convenience. Furthermore, the segment’s proprietorship can be testified by the enlarging solid oral medicine industry, which attained a value of USD 550.0 million in 2022. Additionally, it was observed that 54.0% of the total new drug applications approved by the FDA from 1938 to 2022 had oral administration, as per NLM.

Application Segment Analysis

The histone deacetylase inhibitors market from the oncology segment is set to garner a notable share by the end of 2035. HDAC inhibitors (HDACis) hold a promising avenue in the field of oncology as ongoing research and clinical trials are continually exploring their effectiveness in treating different types of cancers. Moreover, as a novel class of anticancer therapeutic targets, this subtype is highly prioritized by international authorities and drug developers, presenting this medical discipline as a profitable segment. On this note, in November 2023, Acrotech Biopharma received clearance from the FDA for its Belinostat (BELEODAQ) relapsed or refractory peripheral T-cell lymphoma. Further, the Oncologic Drugs Advisory Committee suggested the FDA and Acrotech collaborate to work on mitigating approval delays in oncology.

Our in-depth analysis of the global histone deacetylase inhibitors market includes the following segments:

Classification

  • Class I HDACs
  • Class II HDACs
  •  Class III HDACs

Application

  • Oncology
  • Neurology

Drugs

  • Vorinostat
  • Romidepsin
  •  Belinostat
  •  Panabinostat

End user

  • Hospitals
  • Homecare
  • Specialty Clinics

Distribution Channel

  • Hospital Pharmacy
  • Online Pharmacy
  •  Retail Pharmacy

Route of Administration

  • Oral HDAC Inhibitors
  •  Parenteral HDAC Inhibitors

Browse key industry insights with market data tables & charts from the report:

Frequently Asked Questions (FAQ)

In the year 2026, the industry size of histone deacetylase inhibitors is evaluated at USD 1.53 billion.

The global histone deacetylase inhibitors market size exceeded USD 1.43 billion in 2025 and is set to expand at a CAGR of over 7.6%, surpassing USD 2.97 billion revenue by 2035.

By 2035, North America is predicted to capture a 35.1% share of the histone deacetylase inhibitors market, underpinned by escalating healthcare technology investments and clinical R&D expansion.

Key players in the market include Novartis AG, Midatech Pharma PLC, REGENACY PHARMACEUTICALS, INC., Syndax Pharmaceuticals Inc., Viracta Therapeutics Inc., Xynomic Pharmaceuticals (Nanjing) Co. Ltd., Cetya Therapeutics Inc., Tokyo Chemical Industry Co. Ltd., AstraZeneca Plc.
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