Global Head and Neck Squamous Cell Carcinoma Market Trends, Forecast Report 2025-2037
Head and Neck Squamous Cell Carcinoma Market size is predicted to expand from USD 2.37 billion to USD 7.08 billion, witnessing a CAGR of over 8.7% throughout the forecast period, from 2025 to 2037. In the year 2025, the industry size of head and neck squamous cell carcinoma is evaluated at USD 2.54 billion.
The market growth is driven by increasing cases of head and neck cancer across the world. For instance, head and neck cancer claimed the lives of nearly 280,605 people globally in 2020. Further, worldwide surging demand for combination therapy for the effective treatment of head and neck cancer will spur the market expansion.
In addition, the market revenue is propelled by escalating use of tobacco among the people. Based on the World Health Organization report, in 2020, 36.7% of all men and 7.8% of all women consumed tobacco. This represents 22.3% of the world's population. Additionally, growing advancement in the screening procedure of cancer and a very prominent presence of drugs comprising Avelumab, Ipilimumab, Atezolizumab, and so on will impel the market size. In addition, worldwide escalating demand for non-surgical therapeutics comprising targeted therapy, chemotherapy, and more is anticipated to fuel the market growth.
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Head and Neck Squamous Cell Carcinoma (HNSCC) Sector: Growth Drivers and Challenges
Growth Drivers
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Growing R&D and Approvals for Cancer Drugs and Treatment - Head and neck cancers are treated by using single or combination therapies. Owing to the presence of different types of head and neck cancers, healthcare providers are increasingly working on developing drugs and treatments which apply to treating the disease. Currently, several cancer vaccines for treating head and cancer drugs are under different phases of clinical trials and pharmaceutical manufacturers are spending heavily on research and development to come up with a proper cure for the disease. For instance, the Food and Drug Administration (FDA) has approved several drugs for treating head and neck cancer. Some of them include Bleomycin Sulfate, Cetuximab, Docetaxel, Erbitux, and others.
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Escalating Consumption of Alcohol – Presently, a huge ratio of people have been consuming alcohol and getting the addiction to it. Alcohol is a potent chemical that can negatively impact nearly every part of the human body, namely the heart, bones, and brain. Also, excessive drinking may raise blood pressure and cholesterol levels. Moreover, excessive drinking can increase the risk of mouth cancer and several other types of cancers. Therefore, the escalating consumption of alcohol is also anticipated to fuel market growth in the coming years. For instance, in the United Kingdom, around 49% of adults (aged 16) stated to consume alcohol at least once a week in 2019. Whereas, nearly 57% of men and 44% of women admitted they drank alcohol at least once a week.
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Growing Adoption of Immune Therapeutics - Immune therapeutics or immunotherapy is provided to cancer patients as it possesses numerous benefits over other therapy types. With the growing concern for the increasing number of cancer cases, there is a growing need for treating these patients. Immunotherapy helps the body to combat cancer with its natural defenses. The process further slows or stops the growth of the cancer cells and stops it from spreading. For instance, based on a clinical study estimation conducted in 2020, approximately 44% of cancer patients in the United States were in need of ICI therapy, and approximately 14% of patients responded to it. Such a factor is therefore anticipated to drive the growth of the global head and neck squamous cell carcinoma (HNSCC) treatment and drugs market during the forecast period.
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An Upsurge in Human Papillomavirus (HPV) Infection Cases - Human papillomavirus (HPV) infection is a viral infection that is usually transmitted during intercourse and causes growths on the skin or mucous membranes (warts). HPV also spreads through close skin-to-skin contact during sexual intercourse. A person infected with HPV can infect another person even if they exhibit no symptoms or signs of infection. Thus, HPV may infect the mouth and throat, leading to oropharyngeal cancer that spreads to the back of the throat, including the base of the tongue and tonsils. As per recent estimations, more than 13 million new cases of HPV infection are detected in the United States each year. Hence, the boost in HPV cases is also projected to proliferate the market growth during the forecast period.
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Worldwide Surge in Healthcare Expenditure - According to the World Bank report, worldwide healthcare expenditure grew by 9.83% in 2019.
Challenges
- High Cost of Head & Neck Cancer Treatment and Drugs - Cancer treatments are always extremely costly, especially for individuals belonging to low and middle-income groups. Moreover, the unavailability of proper healthcare standards in several parts of the world is also anticipated to lower the demand for head and neck squamous cell carcinoma (HNSCC) treatment and drugs. The high cost of treatment and drugs is the factor anticipated to lower the market growth during the forecast period.
- Adverse Effects of Concerned Drugs
- Lack of Medical Reimbursement Policies in Emerging Nations
Head and Neck Squamous Cell Carcinoma(HNSCC) Market: Key Insights
Base Year |
2024 |
Forecast Year |
2025-2037 |
CAGR |
8.7% |
Base Year Market Size (2024) |
USD 2.37 billion |
Forecast Year Market Size (2037) |
USD 7.08 billion |
Regional Scope |
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Head and Neck Squamous Cell Carcinoma (HNSCC) Segmentation
Distribution Channel (Hospital Pharmacies, Retail, Online Pharmacies)
The hospital pharmacies segment is estimated to dominate 55% market share by 2037. The segment growth can be attributed to increasing number of cancer patients visiting the hospital for treatments, and therefore they need HNSCC drugs at the hospital premises. For instance, from 2015 to 2019, the number of cancer patients who visited the emergency department in Korea reached around 1,473,120. Nearly 55% of cancer-related ED visits ended in hospitalization, with 6% in ICU, and 10% died in the hospitals. On the other hand, several cancer treatment drugs are restricted for sale on online platforms or even to retail pharmacy outlets.
Drug Class (Immunotherapy, Chemotherapy, Targeted Therapy)
The immunotherapy segment is expected to account for 60% share by 2037, led by significantly growing awareness among people regarding the effectiveness and advantages of cancer immunotherapy over chemotherapy. Furthermore, the surge in drug trials, coupled with the augmenting ratio of novel drugs approval from the authorities such as the FDA and EMA is estimated to drive the segment growth. For instance, Nivolumab (Opdivo) and Pembrolizumab (Keytruda), are two PD-L1 inhibitors, licensed for the treatment of patients with head and neck cancer. Whilst, Dostarlimab (Jemperli) is under phase II clinical trials for head and neck squamous cell carcinoma that has progressed or resurfaced.
On the other hand, the chemotherapy segment is projected to witness a notable CAGR during the forecast period, owing to rising adoption of chemotherapy along with radiation therapy amongst cancer patients worldwide. Moreover, the escalating usage of chemotherapy with the combination of other drugs and therapy has been delivering good outcomes.
Our in-depth analysis of the global market includes the following segments:
By Drug Class |
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By Distribution Channel |
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Customize this ReportHead and Neck Squamous Cell Carcinoma (HNSCC) Industry - Regional Synopsis
North American Market Forecast
The North American head and neck squamous cell carcinoma (HNSCC) market is set to dominate 52% share by 2037. The market growth is due to increasing frequency of head and neck cancer backed by surging ratio of alcohol, and tobacco consumption in people in the region. For instance, around 56,000 cases of oral and pharyngeal cancer are diagnosed in the United States each year, leading to over 12,000 deaths each year.
Moreover, owing to the presence of a strong healthcare network, and the availability of numerous key players in the region, the market for head and neck squamous cell carcinoma (HNSCC) treatment and drugs is anticipated to display significant growth in the North American region. In addition, high awareness among people regarding the disease, along with the presence of favorable reimbursement policies and the availability of quality medical facilities will boost the market revenue.
APAC Market Statistics
The Asia Pacific head and neck squamous cell carcinoma (HNSCC) market is predicted to hold share of over 29% during the forecast period. The market growth is impelled by surging population, coupled with significant increase in the geriatric population, the growing prevalence of smoking, and escalating consumption of alcohol among people in the region. For instance, in 2020, the predicted frequency of any tobacco product consumption among men was around 41% in Malaysia, 38% in Thailand, 47% in South Korea, 30% in Singapore, 15% in Australia, and 10% in Hong Kong. In addition, the escalating prescription of immunotherapy drugs for the effective treatment of several kinds of head and neck cancer will fuel the market size.
Europe Market Forecast
The market in the European region is set to witness moderate growth till 2037, driven by surging ratio of head and neck cancer among people especially men in the region. Moreover, the escalating consumption of alcohol among youngsters is projected to spike the market revenue. In addition, the usage of tobacco and tobacco products by a large pool of the European population has increased in recent years. For instance, in 2021, almost 188 million people, or 28% of the adult population of Europe, were tobacco users.
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Companies Dominating the Head and Neck Squamous Cell Carcinoma (HNSCC) Landscape
- Immutep Limited
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
- Novartis AG
- Fortress Biotech, Inc.
- F. Hoffmann-La Roche Ltd
- Eli Lilly and Company
- Bristol Myers Squibb Company
- AstraZeneca PLC
- Pfizer Inc.
- Boehringer Ingelheim International GmbH
- Checkpoint Therapeutics, Inc.
In the News
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Immutep Limited announced that it has completed the recruitment of patients having head and neck cancer and has safely dosed them for stage 2 of Part C of its Two ACTive Immunotherapies (TACTI-002) Phase II study trials.
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Checkpoint Therapeutics, Inc. announced that it has expanded its partnership with Samsung Biologics Co., Ltd. for manufacturing the anti-PD-L1 antibody, cosibelimab on a commercial scale.
Author Credits: Radhika Pawar
- Report ID: 2839
- Published Date: Jan 28, 2025
- Report Format: PDF, PPT