Atomic Force Microscopy Market Trends

Growth Drivers

• Growth in life sciences applications: The atomic force microscopy is gaining traction in life sciences, in biophysics, molecular diagnostics, and cellular mechanics. Many researchers prefer atomic force microscopy technologies owing to their advanced nanoscale resolution. Moreover, the vital role of AFM in drug development, disease diagnostics, and personalized medicine is projected to fuel its sales growth and job opportunities in the years ahead. The U.S. Bureau of Labor Statistics states that jobs in life, physical, and social sciences are expected to increase at a higher rate than most other jobs from 2023 to 2033. On average, about 148,400 job openings are estimated each year.
   
• Industry 4.0 and smart manufacturing trends: The Industry 4.0 trend is expected to positively influence the sales of atomic force microscopy technologies. In semiconductor and nanomanufacturing environments, atomic force microscopy solutions are widely used for inline, high-resolution surface characterization needs. In August 2025, Appl, Inc. revealed a new USD 100 billion investment in U.S. manufacturing, adding to its existing plans, bringing the total to USD 600 billion over the next four years. Such moves in the manufacturing sector are opening lucrative earning opportunities for AFM manufacturers. Furthermore, the continuous technological advancements coupled with the integration of automation, IoT, and predictive analytics are expected to accelerate the production and commercialization of smart atomic force microscopy technologies.
   
• Increasing adoption in diagnostics: The healthcare sector is emerging as one of the most promising end users for atomic force microscopy technologies. The diagnostics sector is particularly pushing the sales of atomic force microscopy solutions, owing to their ability to capture high-resolution, three-dimensional images of biomolecules, cells, and tissues. Additionally, the rising prevalence of chronic disorders and innovations in diagnostic technologies are further fueling the trade of AFMs. This statement is supported by the World Health Organization’s (WHO) 2024 report on Noncommunicable Diseases. The source states that around 82% of the individuals in the low- and middle-income countries are more susceptible to noncommunicable diseases, also known as chronic disorders. Further, the Centers for Disease Control and Prevention (CDC) in its October 2024 report states that in the U.S., chronic diseases are the leading cause of illness and disability. Thus, for diagnostics and treatment needs, atomic force microscopy technologies are projected to exhibit high application.

Challenges

• High production & operational costs due to safety regulations: The strict safety regulations, such as the Environmental Protection Agency’s (EPA) Toxic Substances Control Act (TSCA), increase the operational costs and make it more challenging for small companies and start-ups. Also, lower budgets limit the expansion of domestic manufacturing units in the developing regions. Some manufacturers miss commercial launch deadlines due to the additional costs of compliance.
   
•  Market access barriers and export restrictions: Barriers to adherence and compliance in the form of non-tariff barriers (NTBs), such as local testing and approval requirements, are keeping AFM exports down, especially to developing countries such as India, Brazil, and China. Many companies faced months of delay due to being governed by the new safety standards for all imported nanotechnology-based instruments. Thus, tariff barriers are expected to hinder the sales of atomic force microscopy solutions to some extent.