Acute Repetitive Seizures Market size is estimated at USD 3.84 billion in 2024 and is poised to reach USD 13.81 billion by the end of 2037, growing at around 15.2% CAGR during the forecast period i.e., between 2025-2037. In 2025, the industry size of acute repetitive seizures is evaluated at USD 4 billion.
The primary growth driver of the acute repetitive seizures (ARS) or cluster seizures is the increasing incidence of epilepsy and related neurological disorders, leading to a heightened demand for effective treatments and management strategies. This demand spurs advancements in drug development, medical devices, and diagnostic tools tailored to managing acute repetitive seizures, thereby expanding the acute repetitive seizures market. For instance, according to a 2021 study published by the National Library of Medicine (NLM), epilepsy affects 0.5-1% of the global population, corresponding approximately to 70 million people. It may be genetic in nature (idiopathic) or develop after brain damage, such as trauma, stroke, infection, tumor growth, or other structural or metabolic causes.
Additionally, the growing adoption of personalized medicine and improved access to healthcare services contribute to the acute repetitive seizures market expansion. Countries investing in healthcare infrastructure, such as the construction of new hospitals and clinics, increase the availability of specialized care for epilepsy and seizure disorders. Moreover, advances in telemedicine have made it easier for patients in remote or underserved areas to access specialist care.
Growth Drivers
Challenges
Base Year |
2024 |
Forecast Year |
2025-2037 |
CAGR |
15.2% |
Base Year Market Size (2024) |
USD 3.84 billion |
Forecast Year Market Size (2037) |
USD 13.81 billion |
Regional Scope |
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Product Type (NRL-1, USL-261, AZ-002, and Diastat Rectal Gel)
The USL-261 segment is estimated to dominate the acute repetitive seizures market with a significant CAGR during the forecast period. The FDA-approved USL-261 (instranasal midazolam) is a rescue therapy for acute treatment of intermittent, stereotypic episodes of frequent seizure activity. It can be used to treat seizure clusters, bouts of increased seizures, or acute repetitive seizures. The drug has become an effective and promising alternative to conventional routes. For instance, according to a 2023 study published by the National Library of Medicine stated that more than 50% of patients responded to the first dose of midazolam and did not experience another seizure with 24 hours after the first. Moreover, no serious adverse events were reported by the patients, making midazolam a relatively safe and well-tolerated option.
USI-261 offers a unique approach or mechanism of action compared to existing treatments, which provide more effective or targeted relief for ARS. By addressing specific unmet needs or offering advantages over existing therapies, USI-261 can differentiate itself in the competitive acute repetitive seizures market, potentially capturing a significant segment.
Our in-depth analysis of the acute repetitive seizures market includes the following segments
Product Type |
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North America Market Analysis
North America in acute repetitive seizures market is projected to dominate around 44.8% revenue share by the end of 2037. The region has a significant population with neurological disorders such as epilepsy, leading to substantial demand for ARS treatments. For instance, according to the Centers for Disease Control and Prevention (CDC), in 2021, around 2.9 million U.S. adults reported having active epilepsy. The growing awareness and better diagnostic capabilities contribute to an increased patient pool. Both the U.S. and Canada have well-developed healthcare systems with extensive access to medical care and treatments. Insurance coverage and reimbursement policies impact the adoption and acute repetitive seizures market growth of new ARS therapies.
In the U.S. significant investment in research and development by pharmaceutical companies and biotech firms leads to continuous innovation in ARS treatments. Advances in drug formulation, targeted therapies, and novel mechanisms of action contribute to market growth. Moreover, engagement with healthcare providers and patient advocacy groups can facilitate adoption and integration of new treatments into standard care practices. The Epilepsy Innovation Institute (EI2), a research program managed by Epilepsy Foundation of America (EFA) fosters new approaches for the diagnosis and treatment of epilepsy and explores bold new ideas and combines novel expertise and technologies from other fields of science
APAC Market Statistics
Asia Pacific acute repetitive seizures market is expected to expand with a notable share by the end of 2037 owing to the increasing diagnosis rates and advancements in treatment options. The diverse healthcare systems impact the availability and adoption of treatments. Countries with more developed healthcare systems, such as Japan and Australia, offer comprehensive, universal healthcare systems that ensure access to essential medical services. This contributes to overall high health outcomes and quality of life for their residents.
In China, the National Medical Products Administration (NMPA) oversees drug approvals. The streamlining of the drug approval process and increased efficiency in regulatory procedures facilitate quicker market entry for new treatments. For instance, in 2024, China NMPA has approved the oral suspension of ganaxolone by Marinus Pharmaceuticals to treat epileptic seizures in patients two years of age and older with CDKL5 deficient disorder (CDD).
In India, NLM estimates about 10 million persons with epilepsy, with a significant proportion experiencing acute repetitive seizures. This high prevalence drives demand for effective treatments and management solutions. Moreover, government initiatives such as the National Program for Prevention and Control of cancer, Diabetes, Cardiovascular Diseases & Stroke (NPCDCS) include components for neurological disorders, including epilepsy.
Companies are developing novel antiepileptic drugs (AEDs) and innovative therapies specially targeting acute repetitive seizures. This includes creating medications with better efficacy, fewer side effects, and improved patient compliance. Moreover, significant investment in research and development helps in discovering new treatment options and understanding seizure mechanisms. Collaborations with other pharmaceutical companies and biotech firms help in co-developing new treatments and sharing technological expertise.
Some of the major key players in acute repetitive seizures market include:
Author Credits: Radhika Pawar
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